4-Bromo-3,5-difluorobenzene-1,2-diamine | 1823344-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Bromo-3,5-difluorobenzene-1,2-diamine
• CAS: 1823344-37-1
• 化学式: C₆H₅BrF₂N₂
• 分子量: 223.02
• InChiKey: MCZQSDPCMGQASV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED HETEROARYLBENZIMIDAZOLE COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROARYLBENZIMIDAZOLE SUBSTITUÉS
  申请人：BAYER PHARMA AG

  公开号：WO2017207534A1

  公开（公告）日：2017-12-07

  The present invention covers substituted heteroarylbenzimidazole compounds of general formula (I) : in which R1, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders disorders, as a sole agent or in combination with other active ingredients.

  本发明涵盖了一般式(I)的取代杂环芳基苯并咪唑化合物：其中R1、R2、R3、R4、R5、R6a和R6b如本文所定义，制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包括所述化合物的药物组合物和组合物，以及用于制造治疗或预防疾病的药物组合物的所述化合物的用途，特别是治疗或预防高增殖和/或炎症性疾病的疾病，作为唯一药剂或与其他活性成分组合使用。
• BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (RORY) AND PHARMACEUTICAL USES THEREOF
  申请人：Jiangsu Hengrui Medicine Co., Ltd.

  公开号：EP3781161A1

  公开（公告）日：2021-02-24
• Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Uses Thereof
  申请人：Jiangsu Hengrui Medicine Co., Ltd.

  公开号：US20210171471A1

  公开（公告）日：2021-06-10

  The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (RORγ) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of RORγ-mediated diseases or disorders.