butane-1-sulfonic acid-(4-hydroxy-anilide) | 51767-47-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butane-1-sulfonic acid-(4-hydroxy-anilide)
• 英文别名: Butan-1-sulfonsaeure-(4-hydroxy-anilid)；N-(4-hydroxyphenyl)butane-1-sulfonamide
• CAS: 51767-47-6
• 化学式: C₁₀H₁₅NO₃S
• mdl: MFCD09881046
• 分子量: 229.3
• InChiKey: RACBQYWVYPUGKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氨基苯酚 、 1-丁基磺酰氯 以81%的产率得到
  参考文献：
  名称：

  HAKAMYPA, TADASI;NAKAMURA, KOITI;YANAGI, XIDEHKI;YAMADZAKI, XARUMASA

  摘要：

  DOI：

文献信息

• SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR
  申请人：Katzenellenbogen A. John

  公开号：US20070021495A1

  公开（公告）日：2007-01-25

  Compounds, pharmaceutically acceptable salts, stereoisomers and prodrugs thereof, that are ER ligands and particularly to such compounds that are ER beta-selective and/or ER beta-specific ligands. Compounds herein include certain compounds which are ER beta-selective agonists. Compounds herein include ER beta-selective agonists which exhibit minimal agonist or antagonist effect on ER alpha. Compounds of the invention include those of formula I: and any pharmaceutically acceptable salts, stereoisomers and prodrugs thereof wherein AR, R 1 , R 3 , and X 1 —X 4 are as defined hereinabove.

  本发明涉及化合物、药学上可接受的盐、立体异构体和前药，它们是ER配体，特别是这些化合物是ER beta选择性和/或ER beta特异性配体。本文化合物包括某些ER beta选择性激动剂。本文化合物包括ER beta选择性激动剂，其在ER alpha上表现出最小的激动或拮抗作用。本发明的化合物包括式I的化合物：以及它们的任何药学上可接受的盐、立体异构体和前药，其中AR、R1、R3和X1-X4如上所定义。
• Silver halide color photographic material
  申请人：KONICA CORPORATION

  公开号：EP0145342A2

  公开（公告）日：1985-06-19

  A silver halide color photographic material is disclosed. The material contains a photographic magenta coupler of formula (I) and a phenolic compound of formula (II) within a silver halide emulsion layer: (wherein R, and R2 are each an alkyl group or an aryl group; Z is a hydrogen or a group that can be eliminated upon coupling reaction with the oxidized product of a color developing agent); (wherein R, is an alkyl group, an alkoxy group, an aryl group or an amino group; R4 is an alkyl group, an alkoxy group or a halogen; s is an integer of 0 to 2, and if s is 2, the two groups R4 may be the same or different).

  本发明公开了一种卤化银彩色感光材料，该材料在卤化银乳剂层中含有式（I）的感光品红耦合剂和式（II）的酚类化合物：（其中 R，和 R2 各为烷基或芳基；Z 为氢或与显色剂的氧化产物发生耦合反应后可消除的基团）；（其中 R，为烷基、烷氧基、芳基或氨基；R4 为烷基、烷氧基或卤素；s 为 0 至 2 的整数，如果 s 为 2，则两个基团 R4 可以相同或不同）。
• Silver halide color photographic light-sensitive material
  申请人：KONICA CORPORATION

  公开号：EP0152296A2

  公开（公告）日：1985-08-21

  Light-sensitive silver halide color photographic material with a magenta deforming layer form magenta dye images having an absorption maximum from 550 nm to 560 nm, with an advantageous absorption spectrum, and exhibit excellent color formability and preservability when the magenta dye images are formed from a 1H-pyrazolo [3,2-C]-s-triazole-type coupler and a pyrazolone-type coupler, said couplers being present in the same silver halide emulsion layer, or in separate silver halide emulsion layers having substantially the same color sensitivity, preferably being green-sensitive.

  具有洋红色变形层的感光卤化银彩色感光材料可形成具有 550 nm 至 560 nm 吸收最大值的洋红色染料图像，并具有有利的吸收光谱，当洋红色染料图像由 1H 吡唑并[3、 2-C]-s-三唑型耦合剂和吡唑酮型耦合剂形成洋红色染料图像时，上述耦合剂存在于同一卤化银乳剂层中，或存在于具有基本相同感色性（最好是绿色感色性）的单独卤化银乳剂层中，可表现出优异的成色性和防腐性。
• Light-sensitive silver halide color photographic material
  申请人：KONICA CORPORATION

  公开号：EP0175573A2

  公开（公告）日：1986-03-26

  A light-sensitive silver halide color photographic materiai, which comprises containing a cyan coupler for photography represented by the formula [1A] or [1B] shown below in the light-sensitive emulsion; where is group having a bulk sufficient to impart diffusion resistance to said coupler; R2 and R3 each represent a hydrogen atom a halogen atom, at least one of R2 and R3 ing a halogen atom; R2 represents an alkyl group, a cycloalkyl group, an alkenyl group or an aryl group; R3 represents a hae- gen atom: and represents a hydrogen atom or a group ehm- nable during the coupling reaction with the oxidized product of a color developing agent. Accoraing to the material of this invention, good spear absorption characteristics can be exhibited and a cyan dye age can be given without dye loss even by use of a bleaching bath or bleach fixing both fatigued after running.

  一种感光型卤化银彩色感光材料，它包括在感光乳剂中含有下式[1A]或[1B]表示的摄影用青色耦合剂； 其中 R2 和 R3 分别代表氢原子和卤素原子，R2 和 R3 中至少有一个代表卤素原子；R2 代表烷基、环烷基、烯基或芳基；R3 代表卤素原子；R2 代表氢原子或在与显色剂的氧化产物发生偶联反应时可被激发的基团。 根据本发明的材料，可以表现出良好的矛吸收特性，即使使用漂白浴或漂白固色剂，也不会造成染料损失。
• Dry analytical element and method for the detection of an aminopeptidase or transpeptidase
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0573100A1

  公开（公告）日：1993-12-08

  A dry analytical element has been prepared for the assay of leucine aminopeptidase at a pH of 6.5 to 11. The element zone contains an aromatic substrate for the enzyme. This substrate provides an aromatic reactant which has a primary amino group on the aromatic ring in the ortho or para position to an electron donor group. The aromatic reactant is oxidized with an oxidizing compound (such as an oxidase) and the oxidized compound reacts with a non-diffusible color-forming coupler to provide a dye.

  我们制备了一种干式分析元件，用于检测 pH 值为 6.5 至 11 的亮氨酸氨肽酶。分析元件区含有酶的芳香底物。这种底物提供了一种芳香族反应物，其芳香环上的伯氨基位于电子供体基团的正位或对位。芳香族反应物被氧化化合物（如氧化酶）氧化，氧化化合物与不可扩散的成色耦合剂反应生成染料。