5-(2-Methyl-6-nitrophenyl)furan-2-carbaldehyde | 1234845-79-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-Methyl-6-nitrophenyl)furan-2-carbaldehyde
• CAS: 1234845-79-4
• 化学式: C₁₂H₉NO₄
• 分子量: 231.208
• InChiKey: JBBVJLNSIZNSGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  76
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(2-Methyl-6-nitrophenyl)furan-2-carbaldehyde 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis, antimicrobial and antioxidant activities of 2-[1-{3,5-diaryl-4,5-dihydro-1H-pyrazolenyl}]-4-(4-nitrophenyl)-[1,3]-thiazoles

  摘要：

  In this study, various substituted chalcones, prepared by condensing substituted acetophenones with substituted aldehydes/arylfurfurals, were treated with thiosemicarbazide in basic media to produce 1-thiocarbonyl-3,5-disubstituted pyrazolines which on further reaction with substituted phenacyl bromides afforded the title compounds in good yield. Structures of the newly synthesized compounds were assigned on the basis of elemental analyses, IR, H-1 NMR, and mass spectral studies. The newly synthesized compounds were tested for their in vitro antibacterial and antifungal activities against a variety of microorganisms and antioxidant activities by diphenylpicrylhydrazyl radical scavenging assay. Among the derivatives, compounds 3b, 3e, 6a, and 6h were identified as potent antioxidants. Compounds 3d, 3e, and 6a-f have emerged as the most promising antimicrobial agents displaying the maximum activity against all the tested microorganisms.

  DOI：

  10.1007/s00044-012-0154-3

文献信息

• Synthesis, Characterization and Biological Studies of Some Bioactive Thiazolotriazole Derivatives
  作者：Manjunatha Kumsi、Boja Poojary、Prajwal Lourdes Lobo、Nalilu Suchetha Kumari、Anoop Chullikana

  DOI：10.1515/znb-2010-1215

  日期：2010.12.1

  anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2,4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities. Graphical Abstract Synthesis, Characterization and Biological Studies of Some Bioactive Thiazolotriazole Derivatives

  从布洛芬 (1) 中以良好的收率合成了关键前体 rac-2-(4-异丁基苯基) 乙基-1,2,4-三唑-5-硫酮 (3)。在乙酸酐和无水乙酸钠存在下，3与5-芳基-呋喃-2-甲醛/取代芳香醛和一氯乙酸在乙酸中的一锅三组分反应得到取代的噻唑并[3,2-b][ 1,2,4]三唑衍生物4和5。通过元素分析和光谱数据阐明了新合成化合物的结构。测试了这些化合物的体外抗微生物活性。一些生物活性噻唑并三唑衍生物的图形摘要合成、表征和生物学研究
• Three-Component Reaction: Synthesis, Characterization, and Biological Study of Some Fused Bridgehead Nitrogen Heterocyclic Systems Containing 4-Methylthiophenyl Moiety
  作者：K. Manjunatha、Boja Poojary、Prajwal L. Lobo、N. Suchetha Kumari、C. Anoop

  DOI：10.1080/10426507.2010.506454

  日期：2011.2.28

  thiazolo-[3,2-b]-1,2,4-triazole derivatives 4 were synthesized by a one-pot, three-component reaction of 3-(4-methylthiobenzyl)-1,2,4-triazole-5-thiol 3, substituted 5-aryl-furan-2-carboxaldehydes/substituted aromatic aldehydes, and monochloroacetic acid in acetic acid using acetic anhydride and anhydrous sodium acetate. Compound 3 was obtained from 4-methylthiophenyl acetic acid by esterification followed

  摘要 通过3-(4-甲硫基苄基)-1,2,4-三唑一锅三组分反应合成了几种取代的噻唑并-[3,2-b]-1,2,4-三唑衍生物4。 -5-硫醇 3、取代的 5-芳基-呋喃-2-甲醛/取代的芳香醛和一氯乙酸在乙酸中使用乙酸酐和无水乙酸钠。化合物 3 由 4-甲硫基苯乙酸通过酯化和肼解获得。通过元素分析和光谱数据阐明了新合成化合物的所有结构。还筛选了新合成的化合物的抗菌和抗炎活性。补充材料可用于本文。转至出版商的在线版磷、硫、和硅和相关元素查看免费的补充文件。图形概要