3-甲基吡啶基-2-硫代甲酰胺 | 334017-95-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-甲基吡啶基-2-硫代甲酰胺
• 英文名称: 3-methylpyridine-2-thiocarboxamide
• 英文别名: 3-methyl-2-pyridine carbothioamide；3-Methylpyridine-2-carbothioamide
• CAS: 334017-95-7
• 化学式: C₇H₈N₂S
• 分子量: 152.22
• InChiKey: PEENLLJOQZUCDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• WGK Germany：
  1

反应信息

• 作为反应物：
  描述：

  3-甲基吡啶基-2-硫代甲酰胺 生成 5-methyl-2-(3-methyl-2-pyridyl)-1,3-thiazole-4-carboxylic acid
  参考文献：
  名称：

  EP1216980

  摘要：

  公开号：

文献信息

• HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR
  申请人：Uchida Hiroshi

  公开号：US20130079306A1

  公开（公告）日：2013-03-28

  A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27 Kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

  提供了一种新型杂环化合物或其盐，用于选择性地抑制p27Kip1的降解。该化合物或其盐由以下式（1）表示：其中A代表烷基、环烷基、芳基或杂环基，基团A可能有取代基；环B代表5至8成员的单环杂环环或包含该单环杂环环的缩合环，环B可能有取代基；环C代表芳香环，环C可能有取代基；L代表包含3至5个原子的主链的连接物，所述原子选自碳原子、氮原子、氧原子和硫原子组成的群，其中主链中的至少一个原子是选自氮原子、氧原子和硫原子组成的杂原子，连接物L可能有取代基；n为0或1。
• Isolation of unique heterocycles formed from pyridine-thiocarboxamides as diiodine, iodide, or polyiodide salts
  作者：Andrew J. Peloquin、Colin D. McMillen、William T. Pennington

  DOI：10.1039/d2ce00904h

  日期：——

  Given their two reactive centers, thioamides serve as useful synthetic building blocks for more complex heterocyclic molecules. The reaction of pyridine-4-thiocarboxamide (1) and pyridine-3-thiocarboxamide (2) with I2 provides protonated forms of the known products 3,5-di-(4-pyridyl)-1,2,4-thiadiazole (1A–1B) and 3,5-di-(3-pyridyl)-1,2,4-thiadiazole (2A–2C), respectively, and yielded new iodide and

  鉴于它们的两个反应中心，硫代酰胺可作为更复杂杂环分子的有用合成构件。吡啶-4-硫代甲酰胺 ( 1 ) 和吡啶-3-硫代甲酰胺 ( 2 ) 与 I 2的反应提供了已知产物 3,5-二-(4-吡啶基)-1,2,4-噻二唑的质子化形式 ( 1A-1B）和3,5-二-（3-吡啶基）-1,2,4-噻二唑（2A-2C），并通过反应溶剂的变化产生新的碘化物和三碘化物盐。吡啶-2-硫代甲酰胺 ( 3 ) 与 I 2的类似反应形成 2,4,6-三(2-吡啶鎓)-1,3,5-三嗪 ( 3A) 而不是含有 1,2,4-噻二唑的产品。吡嗪-、嘧啶-和 5-甲基-吡啶-2-硫代甲酰胺 ( 4-6 ) 在多种溶剂中的反应产生了由两个、三个或四个硫代酰胺等价物缩合形成的其他杂环产物。在这些反应中加入三碘化铋增加了一个额外的操作变量，允许对这些有机产物进行进一步的晶体学研究。四个常见的 BiI 3衍生簇，[Bi 2 I 9
• CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：Eisai Co., Ltd.

  公开号：EP1216980A1

  公开（公告）日：2002-06-26

  The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula (I), a salt thereof, an ester thereof or a hydrate of them. In the formula, R1 represents hydrogen atom, hydroxyl group or a C1-6 alkyl group etc. which may have one or more substituents; L represents a single or double bond or a C1-6 alkylene group etc. which may have one or more substituents; M represents a single bond or a C1-6 alkylene group etc. which may have one or more substituents; T represents a single bond or a C1-3 alkylene group which may have one or more substituents; W represents carboxyl group or a group represented by the formula -CON(Rw1)Rw2 (wherein Rw1 and Rw2 are the same as or different from each other and each represents hydrogen atom, formyl group etc.) etc.; represents a single or double bond; X represents oxygen atom or a C2-6 alkenylene group etc. which may have one or more substituents; Y represents a C5-12 aromatic hydrocarbon group etc. which may have one or more substituents and which may have one or more heteroatoms; and ring Z represents a C5-6 aromatic hydrocarbon group which may have 0 to 4 substituents and which may have one or more heteroatoms.

  本发明提供了一种新型羧酸化合物、其盐或它们的水合物，可用作胰岛素抗性改进剂，以及包含该化合物作为活性成分的药物。也就是说，本发明提供了由下式（I）代表的羧酸化合物、其盐、酯或它们的水合物。 式中，R1 代表氢原子、羟基或 C1-6 烷基等，可有一个或多个取代基；L 代表单键或双键或 C1-6 亚烷基等，可有一个或多个取代基；M 代表单键或 C1-6 亚烷基等，可有一个或多个取代基。W 代表羧基或由式-CON(Rw1)Rw2 所代表的基团（其中 Rw1 和 Rw2 彼此相同或不同，且各自代表氢原子、甲酰基等）等。)等表示的基团；代表单键或双键；X 代表氧原子或 C2-6 烯基等，可有一个或多个取代基；Y 代表 C5-12 芳烃基等，可有一个或多个取代基，可有一个或多个杂原子；环 Z 代表 C5-6 芳烃基，可有 0 至 4 个取代基，可有一个或多个杂原子。
• HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR
  申请人：ASKA Pharmaceutical Co., Ltd.

  公开号：EP2594555B1

  公开（公告）日：2018-03-07
• LEVELING AGENT AND COPPER PLATING COMPOSITION COMPRISING THE SAME
  申请人：SOULBRAIN CO., LTD.

  公开号：US20190161877A1

  公开（公告）日：2019-05-30

  The present invention relates to a additives for electroplating and a copper plating composition comprising the same. Excellently smooth plated surfaces with minimized defects can be obtained when a feature formed on a substrate are plated by using the copper plating composition.