N-[2-(diethylamino)ethyl]-3-methoxy-4-[[4-[[4-methyl-2-[methyl(methylsulfonyl)amino]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | 1226991-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(diethylamino)ethyl]-3-methoxy-4-[[4-[[4-methyl-2-[methyl(methylsulfonyl)amino]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
• CAS: 1226991-60-1
• 化学式: C₂₉H₃₈F₃N₇O₄S
• 分子量: 637.726
• InChiKey: YSLSPMMIGNIFIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  44
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• [EN] 2,4-DIAMINOPYRIMIDINE DERIVATES AS PTK2- INHIBITORS FOR THE TREATMENT OF ABNORMAL CELL GROWTH<br/>[FR] DÉRIVÉS DE 2,4-DIAMINOPYRIMIDINE COMME INHIBITEURS DE PTK2 POUR LE TRAITEMENT D'UNE CROISSANCE CELLULAIRE ANORMALE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010055117A1

  公开（公告）日：2010-05-20

  The present invention encompasses compounds of general formula (1) wherein R1-R3 and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中R1-R3和n如权利要求1所定义的化合物，适用于治疗以细胞过度或异常增殖为特征的疾病，并用于制备具有上述特性的药物。
• 2,4-DIAMINOPYRIMIDINE DERIVATES AS PTK2- INHIBITORS FOR THE TREATMENT OF ABNORMAL CELL GROWTH
  申请人：Sapountzis Ioannis

  公开号：US20110275633A1

  公开（公告）日：2011-11-10

  The present invention encompasses compounds of general formula (1) wherein R 1 -R 3 and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了通式（1）中R1-R3和n的定义如权利要求1所述的化合物，适用于治疗由过度或异常细胞增殖所特征的疾病，并且它们用于制备具有上述特性的药物。