5-Trifluoromethyl-pyridine-2-sulfonic acid {5-tert-butyl-4-[4-hydroxy-6-isopropyl-2-oxo-6-(2-thiophen-3-yl-ethyl)-5,6-dihydro-2H-pyran-3-ylsulfanyl]-2-methyl-phenyl}-amide | 261706-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Trifluoromethyl-pyridine-2-sulfonic acid {5-tert-butyl-4-[4-hydroxy-6-isopropyl-2-oxo-6-(2-thiophen-3-yl-ethyl)-5,6-dihydro-2H-pyran-3-ylsulfanyl]-2-methyl-phenyl}-amide
• 英文别名: 2-Pyridinesulfonamide, N-[4-[[5,6-dihydro-4-hydroxy-6-(1-methylethyl)-2-oxo-6-[2-(3-thienyl)ethyl]-2H-pyran-3-yl]thio]-5-(1,1-dimethylethyl)-2-methylphenyl]-5-(trifluoromethyl)-；N-[5-tert-butyl-4-[[4-hydroxy-6-oxo-2-propan-2-yl-2-(2-thiophen-3-ylethyl)-3H-pyran-5-yl]sulfanyl]-2-methylphenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
• CAS: 261706-64-3
• 化学式: C₃₁H₃₅F₃N₂O₅S₃
• 分子量: 668.823
• InChiKey: OVKAXTKMMVFQLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  168
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• HIV PROTEASE INHIBITORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1112269A2

  公开（公告）日：2001-07-04
• [EN] HIV PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTEASE DU VIH
  申请人：WARNER LAMBERT CO

  公开号：WO2000015634A2

  公开（公告）日：2000-03-23

  The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.