1-(4-pyridin-4-ylpiperazin-1-yl)-3-(4-trifluoromethyl-phenyl)propan-1-one | 485796-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(4-pyridin-4-ylpiperazin-1-yl)-3-(4-trifluoromethyl-phenyl)propan-1-one
• 英文别名: 1-(4-Pyridin-4-ylpiperazin-1-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-one
• CAS: 485796-82-5
• 化学式: C₁₉H₂₀F₃N₃O
• 分子量: 363.383
• InChiKey: UGWCNBGWAUNMFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Substituted piperazines and diazepanes
  申请人：Dorwald Florencio Zaragoza

  公开号：US20080113968A1

  公开（公告）日：2008-05-15

  A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的取代哌嗪和二氮平类化合物，包括它们的药物组合物及其在治疗与组胺H3受体相关的疾病和障碍中的用途。特别地，这些化合物可用于治疗与组胺H3受体相互作用有益的疾病和障碍。
• KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES
  申请人：Flynn Daniel L.

  公开号：US20080269267A1

  公开（公告）日：2008-10-30

  Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, a disease caused by c-Met kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by a Raf kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.

  本发明的化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性黑色素瘤、实体肿瘤、胶质母细胞瘤、卵巢癌、胰腺癌、前列腺癌、肺癌、乳腺癌、肾癌、肝癌、宫颈癌、原发肿瘤部位的转移、骨髓增生性疾病、慢性髓细胞白血病、白血病、乳头状甲状腺癌、非小细胞肺癌、间皮瘤、高嗜酸性综合征、胃肠道间质瘤、结肠癌、眼部疾病，其特征是过度增殖导致失明，包括各种视网膜病变、糖尿病性视网膜病变、类风湿性关节炎、哮喘、慢性阻塞性肺疾病、肥大细胞增多症、肥大细胞白血病、由c-Abl激酶引起的疾病、其致癌形式、异常融合蛋白和多态体，由c-Kit激酶引起的疾病、其致癌形式、异常融合蛋白和多态体，由c-Met激酶引起的疾病、其致癌形式、异常融合蛋白和多态体，或由Raf激酶引起的疾病、其致癌形式、异常融合蛋白和多态体。
• SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS
  申请人：High Point Pharmaceuticals, LLC

  公开号：EP1421071B1

  公开（公告）日：2009-11-18
• US7208497B2
  申请人：——

  公开号：US7208497B2

  公开（公告）日：2007-04-24