Poly(oxy-1,2-ethanediyl), I+/--(2,5-dioxo-1-pyrrolidinyl)-I-hydroxy- | 146572-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Poly(oxy-1,2-ethanediyl), I+/--(2,5-dioxo-1-pyrrolidinyl)-I-hydroxy-
• 英文别名: 1-(2-hydroxyethoxy)pyrrolidine-2,5-dione
• CAS: 146572-71-6
• 化学式: C₆H₉NO₄
• 分子量: 159.14
• InChiKey: BSDRJHCPCRCRAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Derivatized poly(ester amide) as a biobeneficial coating
  申请人：Hossainy Faiyaz Ahmed Syed

  公开号：US20060115513A1

  公开（公告）日：2006-06-01

  A derivatized poly(ester amide) (D-PEA) and coatings and medical devices formed therefrom are provided. The coatings and medical devices may optionally include a biobeneficial material and/or a biocompatible polymer and/or a bioactive agent. The medical devices can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

  本文提供了一种衍生化聚（酯酰胺）（D-PEA）以及由其形成的涂层和医疗器械。涂层和医疗设备可选择包括生物有益材料和/或生物相容性聚合物和/或生物活性剂。这些医疗器械可植入患者体内，以治疗、预防或改善动脉粥样硬化、血栓形成、血管再狭窄、出血、血管剥离或穿孔、血管动脉瘤、脆弱斑块、慢性全闭塞、跛行、静脉和人工移植物吻合口增生、胆管阻塞、输尿管阻塞、肿瘤阻塞等疾病或其组合。
• DERIVATIZED POLY (ESTER AMIDE) AS A BIOBENEFICIAL COATING
  申请人：Abbott Cardiovascular Systems Inc.

  公开号：EP1828329A2

  公开（公告）日：2007-09-05
• GLUCOCEREBROSIDASE MULTIMERS AND USES THEREOF
  申请人：Protalix Ltd.

  公开号：EP2542674A1

  公开（公告）日：2013-01-09
• US8609123B2
  申请人：——

  公开号：US8609123B2

  公开（公告）日：2013-12-17
• [EN] DERIVATIZED POLY (ESTER AMIDE) AS A BIOBENEFICIAL COATING<br/>[FR] POLY(ESTER AMIDE) DERIVE UTILISE COMME REVETEMENT BIOLOGIQUEMENT AVANTAGEUX
  申请人：ADVANCED CARDIOVASCULAR SYSTEM

  公开号：WO2006058122A2

  公开（公告）日：2006-06-01

  [EN] A derivatized poly(ester amide) (D-PEA) and coatings and medical devices formed therefrom are provided. The coatings and medical devices may optionally include a biobeneficial material and/or a biocompatible polymer and/or a bioactive agent. The medical devices can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
  [FR] Cette invention concerne un poly(ester amide) dérivé (D-PEA) ainsi que des revêtements et des dispositifs médicaux formés à partir de celui-ci. Les revêtements et les dispositifs médicaux peuvent éventuellement comprendre un matériau biologiquement avantageux et/ou un polymère biocompatible et/ou un agent bioactif. Les dispositifs médicaux peuvent être implantés dans un patient pour traiter, prévenir ou améliorer un trouble tel que l'athérosclérose, la thrombose, la resténose, l'hémorragie, la dissection ou la perforation vasculaire, l'anévrisme vasculaire, la plaque vulnérable, l'occlusion totale chronique, la claudication, la prolifération anastomotique pour les veines et les greffes artificielles, l'obstruction du canal cholédoque, l'obstruction urétrale, l'obstruction tumorale ou des combinaison de ceux-ci.