1-(cyclopropylcarbonyl)-4-[1-(diphenylmethyl)azetidin-3-yl]piperazine | 930782-96-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(cyclopropylcarbonyl)-4-[1-(diphenylmethyl)azetidin-3-yl]piperazine
• 英文别名: [4-(1-Benzhydrylazetidin-3-yl)piperazin-1-yl]-cyclopropylmethanone
• CAS: 930782-96-0
• 化学式: C₂₄H₂₉N₃O
• 分子量: 375.514
• InChiKey: CKAPVHNMGITHJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel Azetidine Compounds Useful in the Treatment of Functional Gastrointestinal Disorders, Ibs and Functional Dyspepsia
  申请人：Bergman Rolf

  公开号：US20100311713A1

  公开（公告）日：2010-12-09

  The present invention relates to new azetidine compounds, to pharmaceutical compositions containing them and the use of said compounds in the treatment of functional gastrointestinal disorders, IBS and functional dyspepsia. The compounds are neurokinin (NK) antagonists. The present invention further relates to processes for the preparation of the compounds.

  本发明涉及新的氮杂四元环化合物，以及含有它们的制药组合物和在功能性胃肠障碍、肠易激综合征和功能性消化不良治疗中使用的该类化合物。这些化合物是神经激肽（NK）拮抗剂。本发明还涉及制备该类化合物的方法。
• NOVEL AZETIDINE COMPOUNDS USEFUL IN THE TREATMENT OF FUNCTIONAL GASTROINTESTINAL DISORDERS, IBS AND FUNCTIONAL DYSPEPSIA
  申请人：Albireo AB

  公开号：EP1940845B1

  公开（公告）日：2013-06-12
• US8288370B2
  申请人：——

  公开号：US8288370B2

  公开（公告）日：2012-10-16
• [EN] NOVEL AZETIDINE COMPOUNDS USEFUL IN THE TREATMENT OF FUNCTIONAL GASTROINTESTINAL DISORDERS, IBS AND FUNCTIONAL DYSPEPSIA<br/>[FR] NOUVEAUX COMPOSES D'AZETIDINE UTILES DANS LE TRAITEMENT DE TROUBLES GASTRO-INTESTINAUX FONCTIONNELS, DE L'IBS ET DE LA DYSPEPSIE FONCTIONNELLE
  申请人：ASTRAZENECA AB

  公开号：WO2007037743A1

  公开（公告）日：2007-04-05

  [EN] The present invention relates to new azetidine compounds, to pharmaceutical compositions cotaining them and the use of said compounds in in the treatment of functional gastrointestinal disorders, IBS and functional dyspepsia. The compounds are neurokinin (NK) antagonists . The present invention further relates to processes for the preparation of the compounds.
  [FR] La présente invention concerne de nouveaux composés d'azétidine, des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés dans le traitement de troubles gastro-intestinaux fonctionnels, de l'IBS et de la dyspepsie fonctionnelle. Les composés de l'invention sont des antagonistes de la neurokinine (NK). L'invention concerne en outre des méthodes de préparation desdits composés.