N¹-(2-Naphthyl)-biguanid | 5426-97-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N¹-(2-Naphthyl)-biguanid
• 英文别名: Naphthyl-(2)-biguanid；1--biguanid；1-[2]naphthyl-biguanide；ο-(β-Naphthyl)-biguanid；N-β-Naphthyl-N'-guanyl-guanidin；1-[2]Naphthyl-biguanid；N-2-naphthylimidodicarbonimidic diamide；1-(diaminomethylidene)-2-naphthalen-2-ylguanidine
• CAS: 5426-97-1
• 化学式: C₁₂H₁₃N₅
• mdl: MFCD03615420
• 分子量: 227.269
• InChiKey: RDLIBCPWPNCFBW-UHFFFAOYSA-N

物化性质

• 溶解度：
  0.00 M

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N¹-(2-Naphthyl)-biguanid 在 盐酸 作用下， 生成 N-carbamimidoyl-N'-[2]naphthyl-urea
  参考文献：
  名称：

  Urbanski et al., Roczniki Chemii, 1959, vol. 33, p. 1383,1387

  摘要：

  DOI：
• 作为产物：
  描述：

  2-萘胺盐酸盐 、 二聚氰胺 生成 N¹-(2-Naphthyl)-biguanid
  参考文献：
  名称：

  770.氨基氧基衍生物。第三部分 二氢三嗪和相关杂环

  摘要：

  DOI：

  10.1039/jr9620003915

文献信息

• US2320882
  申请人：——

  公开号：——

  公开（公告）日：——
• Raman et al., Journal of the Indian Institute of Science, Section A, 1953, vol. 35, p. 247
  作者：Raman et al.

  DOI：——

  日期：——
• [EN] 5-HT3 RECEPTOR ANTAGONISTS FOR TREATMENT OF DISORDERS INVOLVING AIRWAY CONSTRICTION<br/>[FR] ANTAGONISTES DU RECEPTEUR 5-HT3 DESTINES AU TRAITEMENT DE TROUBLES ENGLOBANT LA CONSTRICTION DES VOIES AERIENNES
  申请人：RESPIRATORIUS AB

  公开号：WO2001095903A1

  公开（公告）日：2001-12-20

  The present invention relates to a compound having antagonist activity to the 5-HT3 receptor for use as a medicament and to the use of said compound in the manufacture of a medicament for use in therapeutic or prophylactic treatment of disorders involving airway constriction of a human or animal body, as well as methods of treatment, wherein said compounds are administered.
• [EN] A COMPOSITION COMPRISING A COMBINATION OF RECEPTOR AGONISTS AND ANTAGONISTS<br/>[FR] COMPOSITION CONTENANT UNE ASSOCIATION D'AGONISTES ET D'ANTAGONISTES D'UN RECEPTEUR
  申请人：RESPIRATORIUS AB

  公开号：WO2001095902A1

  公开（公告）日：2001-12-20

  The present invention relates to a composition comprising a combination of a) at least one compound with agonist activity to the 5-HT4 receptor and b) at least one compound with antagonist activity to the 5-HT3 receptor and to the use of said compound in the manufacture of a medicament for therapeutic or prophylactic treatment of disorders involving airway constriction of a human or animal body, as well as methods of treatment, wherein said compounds are administered.
• [EN] COMPOSITION COMPRISING SEROTONIN RECEPTOR ANTAGONISTS, 5 HT-2 AND 5 HT-3<br/>[FR] COMPOSITION COMPRENANT LES ANTAGONISTES DES RECEPTEURS DE SEROTONINE 5 HT-2 ET 5 HT-3
  申请人：RESPIRATORIUS AB

  公开号：WO2002036114A1

  公开（公告）日：2002-05-10

  A composition comprising a combination of compounds comprising: a) at least one compound with antagonist activity to the 5-HT3 receptor; and b) at least one compound with antagonist activity to the 5-HT2 receptor is described.