4-叠氮基-2-羟基-N-[2-(2-吡啶基二硫基)乙基]苯甲酰胺 | 164575-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-叠氮基-2-羟基-N-[2-(2-吡啶基二硫基)乙基]苯甲酰胺
• 英文名称: S-[2-(4-Azidosalicylamido)ethylthio]-2-thiopyridine
• 英文别名: 4-azido-2-hydroxy-N-[2-(pyridin-2-yldisulfanyl)ethyl]benzamide
• CAS: 164575-82-0
• 化学式: C14H13N5O2S2
• 分子量: 347.4
• InChiKey: YELWNIMQOUETBV-UHFFFAOYSA-N

物化性质

• 熔点：
  119-121°C
• 溶解度：
  易溶于可溶于氯仿、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Activatable probes and methods for in vivo gene detection
  申请人：Bao Gang

  公开号：US20050287548A1

  公开（公告）日：2005-12-29

  Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.

  提供用于检测靶向多核苷酸的探针。一个方面提供了一种分子信标探针集合，其中供体分子信标包括量子点，受体分子信标包括至少一个报告基团。这些探针可以选择性地包括蛋白质转导域、靶向信号或二者的组合。还提供了使用所述探针检测靶向多核苷酸的方法。
• CROSSLINKING REAGENTS, METHODS, AND COMPOSITIONS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS
  申请人：Huang Yumei

  公开号：US20120322978A1

  公开（公告）日：2012-12-20

  The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo and in vitro. Advantages offered by various embodiments of the inventive system and methods compared to existing photocrosslinking approaches include, for example, (i) novel reversible crosslinking reagents that allow easy isolation, purification, and enrichment of the crosslinked products; (ii) trifluoromethyl phenyldiazirine- or perfluorinated phenylazide-based photocrosslinking reagents that provide high specific labeling, no side product, and higher photocrosslinking efficiency; (iii) versatile spacer groups that allow systematic contact site mapping; (iv) novel methods for isolating, purifying, and detecting crosslinked products based on the reversible-link chemistry; and (v) the ability to study the interaction sites in vitro, in situ, or in vivo.

  该发明提供了用于研究蛋白质-蛋白质相互作用的试剂、方法和组合物。这一创新系统和方法允许在体内和体外分析蛋白质-蛋白质相互作用。与现有的光交联方法相比，该创新系统和方法的各种实施例提供的优势包括：（i）新型可逆交联试剂，可方便地分离、纯化和富集交联产物；（ii）三氟甲基苯基重氮基或全氟苯基偶氮基光交联试剂提供高特异标记、无副产物和更高的光交联效率；（iii）多功能的间隔基团，可进行系统的接触位点映射；（iv）基于可逆链接化学的新方法用于分离、纯化和检测交联产物；以及（v）能够在体外、原位或体内研究相互作用位点。
• MACROMOLECULAR CONJUGATES OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREFOR
  申请人：Verkman Alan S.

  公开号：US20080171793A1

  公开（公告）日：2008-07-17

  Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.

  本文提供了生物活性剂，其中包括一种抑制囊性纤维化跨膜导电调节因子（CFTR）离子传输活性的化合物，并且与与表达CFTR的细胞相互作用的大分子相连。本文所描述的生物活性剂可用于治疗与CFTR活性异常增加相关的疾病、疾病后遗症和疾病、疾病后遗症和病症，例如分泌性腹泻。
• Polymer Support
  申请人：Jardine Moegamat Anwar

  公开号：US20120178916A1

  公开（公告）日：2012-07-12

  The invention provides a polymer support characterised in that the polymer is 6-amino 6-deoxy chitosan. Metal-immobilised 6-amino 6-deoxy chitosan is further provided, more particularly including one of Pd, Pt, Ru, Rh Ir, Os, Mn, Ni, Co and Fe in all their possible oxidation states complexed to 6-amino 6-deoxy chitosan through a Schiff-base ligand.

  本发明提供了一种聚合物支撑，其特征在于聚合物是6-氨基6-脱氧壳聚糖。此外，还提供了金属固定的6-氨基6-脱氧壳聚糖，更具体地包括Pd、Pt、Ru、Rh、Ir、Os、Mn、Ni、Co和Fe中的一种或多种，它们的所有可能的氧化态通过席夫碱配体络合到6-氨基6-脱氧壳聚糖上。
• ANTIBODIES SELECTIVE FOR PATHOLOGICAL TAU DIMERS AND PREFIBRILLAR PATHOLOGICAL TAU OLIGOMERS AND THEIR USES IN TREATMENT, DIAGNOSIS AND MONITORING OF TAUOPATHIES
  申请人：Binder Lester I.

  公开号：US20120301473A1

  公开（公告）日：2012-11-29

  Antibodies selective for pathological tau dimers and/or prefibrillar pathological tau oligomers, immunogenic peptides and epitopes of these antibodies, hydridomas producing these antibodies, uses of these antibodies, immunogenic peptides and epitopes in preparation of pharmaceutical compositions for the treatment of tauopathies, and uses of these antibodies, immunogenic peptides, epitopes and pharmaceutical compositions in the treatment of tauopathies are described. Also described are uses of these antibodies, immunogenic peptides, epitopes in diagnosis and monitoring of tauopathies.

  本文描述了选择性针对病理性tau二聚体和/或前纤维病理性tau寡聚体的抗体、这些抗体的免疫原肽和表位、产生这些抗体的杂交瘤、这些抗体、免疫原肽和表位在制备用于治疗tau病理学的药物组合物中的用途以及这些抗体、免疫原肽、表位和药物组合物在治疗tau病理学中的用途。还描述了这些抗体、免疫原肽、表位在tau病理学的诊断和监测中的用途。