1-(5'-hydroxy-2'-nitrophenyl)-2-propen-1-ol | 187793-42-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-(5'-hydroxy-2'-nitrophenyl)-2-propen-1-ol
• 英文别名: 3-(1-Hydroxyprop-2-en-1-yl)-4-nitrophenol；3-(1-hydroxyprop-2-enyl)-4-nitrophenol
• CAS: 187793-42-6
• 化学式: C₉H₉NO₄
• 分子量: 195.175
• InChiKey: AERPLYFHHMHCQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(5'-hydroxy-2'-nitrophenyl)-2-propen-1-ol 在 Jones reagent 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以83%的产率得到1-(5-Hydroxy-2-nitrophenyl)prop-2-en-1-one
  参考文献：
  名称：

  METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS

  摘要：

  公开号：

  EP1378505B1
• 作为产物：
  描述：

  5-羟基-2-硝基苯甲醛 在 盐酸 作用下， 以 乙烯基溴化镁 为溶剂， 以73%的产率得到1-(5'-hydroxy-2'-nitrophenyl)-2-propen-1-ol
  参考文献：
  名称：

  S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and

  摘要：

  一种制备S型2-取代羟基-2-吲哚丁酸酯化合物的方法\x9bII!：##STR1##其中R.sup.o是氮杂环羧酸的残基，具有“R”的绝对构型（其中氮原子被保护），R.sup.1和R.sup.2是较低的烷基基团，E是酯基团，可用作制备具有抗肿瘤活性的紫杉醇衍生物的中间体，包括对2-取代羟基-2-吲哚丁酸乙酯化合物进行乙酰化的步骤\x9bI!：##STR2##其中符号如上定义。

  公开号：

  US05932732A1

文献信息

• Camptothecin derivatives
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US05837673A1

  公开（公告）日：1998-11-17

  A camptothecin derivative comprising a compound of the formula \x9bI!: ##STR1## wherein R.sup.1 is a substituted or unsubstituted lower alkyl group, X.sup.1 is a group of the formula: --NHR.sup.2 (R.sup.2 is a hydrogen atom or a lower alkyl group) or a group of --OH, and Alk is a straight chain or branched chain alkylene group having optionally an oxygen atom in the chain thereof, bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects unlike conventional anticancer agents, and hence, these compounds are extremely useful as a medicament.

  一种紫杉醇衍生物，包括具有以下结构的化合物：其中R.sup.1是取代或未取代的较低烷基基团，X.sup.1是以下结构的一个基团：--NHR.sup.2（其中R.sup.2是氢原子或较低烷基基团）或--OH的基团，Alk是一种直链或支链烷基烃基团，该基团在链中可能有一个氧原子，通过氨基酸或肽键结合到具有羧基的多糖上，或其药学上可接受的盐。所述紫杉醇衍生物显示出增强的抗肿瘤活性，但与传统的抗癌药物相比副作用较少，因此，这些化合物作为药物非常有用。
• S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：US20030135049A1

  公开（公告）日：2003-07-17

  A process for preparing S type 2-substituted hydroxy-2-indolidinylbutyric ester compound [II]: 1 wherein R o is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of “R” (in which the nitrogen atom is protected), R1 and R2 are lower alkyl groups, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities, which comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]: 2 wherein the symbols are as defined above.

  一种制备S型2-取代羟基-2-吲哚丁酸酯化合物II的方法：其中Ro是氮杂环羧酸残基，具有“R”的绝对构型（其中氮原子受保护），R1和R2是较低的烷基基团，E是酯残基，该化合物是制备具有抗肿瘤活性的喜树碱衍生物的中间体，包括对2-取代羟基-2-吲哚丁酸乙酯化合物I进行2-乙基化，其中符号如上所定义。
• Stype 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US20020161231A1

  公开（公告）日：2002-10-31

  A process for preparing S type 2-substituted hydroxy-2-indolidinylbutyric ester compound [II]: 1 wherein R o is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of “R” (in which the nitrogen atom is protected), R1 and R2 are lower alkyl groups, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities, which comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]: 2 wherein the symbols are as defined above.

  一种制备S型2-取代羟基-2-吲哚丁酸酯化合物II的方法：其中Ro是氮杂环羧酸残基，具有“R”的绝对构型（其中氮原子受保护），R1和R2是低烷基基团，E是酯基残基，可用作制备具有抗肿瘤活性的喜树碱衍生物的中间体，该方法包括对2-取代羟基-2-吲哚乙酸酯化合物I进行2-乙基化，其中符号如上所定义。
• Nitrogen-containing fused heterocyclic carboxylic acids having an absolute configuration of “R”
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US07060832B2

  公开（公告）日：2006-06-13

  Nitrogen-containing fused heterocyclic carboxylic acid having an absolute configuration of “R” of the formula [XIX]: wherein Y is substituted or unsubstituted arylsulfonyl group or an alkylsulfonyl group, and n is 0 or 1, or a salt thereof.

  具有绝对构型“R”的含氮融合杂环羧酸的化学式[XIX]，其中Y是取代或未取代的芳基磺酰基或烷基磺酰基，n为0或1，或其盐。
• S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds as intermediates for camptothecin derivatives
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0845464A2

  公开（公告）日：1998-06-03

  A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound [II]: wherein R° is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nitrogen atom is protected), R1 and R2 are lower alkyl group, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities,    comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]: wherein the symbols are as defined above.

  一种制备 S 型 2-取代羟基-2-吲哚烷基丁酸酯化合物的工艺[II]： 其中 R°为绝对构型为 "R"（其中氮原子被保护）的含氮融合杂环羧酸残基，R1 和 R2 为低级烷基，E 为酯残基，可用作制备具有抗肿瘤活性的喜树碱衍生物的中间体、 包括 2-乙基化 2-取代羟基-2-吲哚乙酸酯化合物[I]： 其中符号如上定义。