hydroxy-benzene-1,2,3,4-tetracarboxylic acid | 4961-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hydroxy-benzene-1,2,3,4-tetracarboxylic acid
• 英文别名: Hydroxy-benzol-1,2,3,4-tetracarbonsaeure；Phenol-tetracarbonsaeure-(2.3.4.5)；5-Hydroxy-1,2,3,4-benzenetetracarboxylicsaeure；5-Hydroxybenzene-1,2,3,4-tetracarboxylic acid
• CAS: 4961-06-2
• 化学式: C₁₀H₆O₉
• 分子量: 270.152
• InChiKey: DLKFGKSMNUFVSR-UHFFFAOYSA-N

物化性质

• 熔点：
  241-243 °C
• 沸点：
  612.7±55.0 °C(Predicted)
• 密度：
  1.957±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  169
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-hydroxy-3-hydroxyoxalyl-benzene-1,2,4-tricarboxylic acid 在 硫酸 作用下， 生成 hydroxy-benzene-1,2,3,4-tetracarboxylic acid
  参考文献：
  名称：

  Transgenes in F4 pMThGH-transgenic common carp (Cyprinus carpio L.) are highly polymorphic

  摘要：

  To gain information on the integration pattern of pMThGH-transgene, 50 transgenes were recovered from F-4 generation of pMThGH transgenic common carp (Cyprinus carpio L,) and 33 recovered genes were analyzed. The restriction maps of these recovered genes were constructed by digestion with five kinds of enzymes. These transgenes can be classified into 4 types according to their restriction maps. Only one type of transgenes maintains its original molecular form, whereas the other three types are very different from the original one and vary each other on both molecular weight and restriction maps. This implies that the sequences of most transgenes have been deleted and/or rearranged during integration and inheritance. The results of PCR amplification and Southern blot hybridization indicate that MThGH in Type I transgene keeps intact but most of its sequence has been deleted in other three types. All these results suggest that transgenes in F-4 generation of transgenic carp are highly polymorphic. Two DNA fragments concerning integration site of transgenes were cloned from recovered transgenes, and found to be homologous to the 5'UTR of beta -actin gene of common carp and mouse mRNA for receptor tyrosine kinase (RTK), respectively.

  DOI：

  10.1007/bf03187011

文献信息

• [EN] AROMATIC COMPOUNDS FROM FURANICS<br/>[FR] COMPOSÉS AROMATIQUES DÉRIVÉS DES FURANIQUES
  申请人：NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

  公开号：WO2017146581A1

  公开（公告）日：2017-08-31

  Described are methods for preparing phenols, benzene carboxylic acids, esters and anhydrides thereof from furanic compounds by reaction with a dienophile, wherein the furanic compounds are reacted with a hydrazine and/or oxime and then reacted with a dienophile.

  描述了一种从呋喃化合物通过与二烯醚反应制备酚、苯甲酸、酯和酐的方法，其中呋喃化合物与肼和/或肟反应，然后与二烯醚反应。
• [EN] PRODUCTION OF AROMATIC ACIDS AND PHENOLICS<br/>[FR] PRODUCTION D'ACIDES AROMATIQUES ET DE COMPOSÉS PHÉNOLIQUES
  申请人：TNO

  公开号：WO2021080426A1

  公开（公告）日：2021-04-29

  The invention is directed to a process for the preparation of an aromatic acid or a phenolic compound, said process comprising reacting a dienophile and a furanic compound comprising an acetal moiety in a Diels-Alders reaction to obtain an aromatic compound comprising said acetal moiety, followed by hydrolysis and oxidation of said acetal moiety into a hydroxide or carboxylate moiety to form the aromatic acid or phenolic compound, wherein said dienophile is selected from the group consisting of alkylenes, acetylenes, acrylates, maleates, fumarates, maleimides, propiolates, acetylene dicarboxylates, and benzynes and wherein said acetal moiety is bound directly to the 2-position of the furanic compound.

  该发明涉及一种制备芳香酸或酚类化合物的方法，该方法包括将二烯酸酯和含有缩醛基团的呋喃化合物在Diels-Alder反应中反应，以获得含有该缩醛基团的芳香化合物，随后对该缩醛基团进行水解和氧化，将其转化为羟基或羧酸基团，形成芳香酸或酚类化合物。其中，所述二烯酸酯选自烯烃、乙炔、丙烯酸酯、马来酸酯、富马酸酯、马来酰亚胺、丙炔酸酯、乙炔二羧酸酯和苯炔，所述缩醛基团直接与呋喃化合物的2位结合。
• PRODUCTION OF AROMATIC ACIDS AND PHENOLICS
  申请人：Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO

  公开号：EP3812361A1

  公开（公告）日：2021-04-28

  The invention is directed to a process for the preparation of an aromatic acid or a phenolic compound, said process comprising reacting a dienophile and a furanic compound comprising an acetal moiety in a Diels-Alders reaction to obtain an aromatic compound comprising said acetal moiety, followed by hydrolysis and oxidation of said acetal moiety into a hydroxide or carboxylate moiety to form the aromatic acid or phenolic compound, wherein said dienophile is selected from the group consisting of alkylenes, acetylenes, acrylates, maleates, fumarates, maleimides, propiolates, acetylene dicarboxylates, and benzynes and wherein said acetal moiety is bound directly to the 2-position of the furanic compound.

  本发明涉及一种制备芳香族酸或酚类化合物的工艺，所述工艺包括在 Diels-Alders 反应中使亲二烯化合物和包含缩醛分子的呋喃化合物反应，得到包含所述缩醛分子的芳香族化合物、随后将所述缩醛基团水解和氧化成氢氧化物或羧酸基团，形成芳香族酸或酚类化合物，其中所述亲二烯基团选自由烯烃、炔烃、丙烯酸酯、马来酸酯、富马酸酯、马来酰亚胺、丙醇酯、乙炔二羧酸酯和苄基化合物组成的组，且所述缩醛基团直接与呋喃化合物的 2-位结合。
• Aromatic compounds from furanics
  申请人：Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO

  公开号：US10562875B2

  公开（公告）日：2020-02-18

  Described are methods for preparing phenols, benzene carboxylic acids, esters and anhydrides thereof from furanic compounds by reaction with a dienophile, wherein the furanic compounds are reacted with a hydrazine and/or oxime and then reacted with a dienophile.

  描述了通过与亲二烯反应从呋喃化合物制备苯酚、苯羧酸、其酯和酸酐的方法，其中呋喃化合物与肼和/或肟反应，然后与亲二烯反应。
• AROMATIC COMPOUNDS FROM FURANICS
  申请人：Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO

  公开号：EP3419957A1

  公开（公告）日：2019-01-02