3-[3'-(trifluoromethyl)phenyl]-3-hydroxybutanamide | 1163136-34-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[3'-(trifluoromethyl)phenyl]-3-hydroxybutanamide
• 英文别名: 3-Hydroxy-3-[3-(trifluoromethyl)phenyl]butanamide
• CAS: 1163136-34-2
• 化学式: C₁₁H₁₂F₃NO₂
• 分子量: 247.217
• InChiKey: VGLHGKUGVWSUFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] FLUORINATED ARYL AMIDE COMPOUNDS<br/>[FR] COMPOSÉS FLUORÉS D'ARYLE ET D'AMIDE
  申请人：CASCADE THERAPEUTICS INC

  公开号：WO2009079763A1

  公开（公告）日：2009-07-02

  A compound of Formula I : The compound can be used in the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders.

  化合物I的公式为：该化合物可用于治疗癫痫、神经病性疼痛、急性和慢性炎症性疼痛、偏头痛、迟发性运动障碍和其他相关的中枢神经系统疾病。
• NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
  申请人：Pesyan Amir

  公开号：US20110046128A1

  公开（公告）日：2011-02-24

  A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.

  本文介绍了一系列新型化合物，具有抗惊厥、化学对抗剂和镇痛活性。这些药物活性化合物也可能在治疗其他中枢神经系统（“CNS”）疾病和障碍方面发挥作用，如焦虑、抑郁、失眠、偏头痛、精神分裂症、帕金森病、痉挛、阿尔茨海默病和双相情感障碍。此外，这些化合物还可以作为镇痛剂（例如，用于慢性或神经性疼痛的治疗）和作为神经保护剂，有助于治疗中风、慢性神经退行性疾病（如阿尔茨海默病和亨廷顿病）以及创伤性脑和/或脊髓损伤。此外，这些化合物还可以用于治疗癫痫持续状态和/或作为化学对抗剂。
• US9212155B2
  申请人：——

  公开号：US9212155B2

  公开（公告）日：2015-12-15