| 2755794-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• CAS: 2755794-40-0
• 化学式: 0C₄H₆O₆*C₂₁H₂₀ClF₃N₄O₃S
• 分子量: 575.973
• InChiKey: UBUWCSONGKHQGM-LREBCSMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.73
• 重原子数：
  43.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  193.95
• 氢给体数：
  4.0
• 氢受体数：
  11.0

反应信息

• 作为产物：
  描述：

  L-酒石酸 、 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one 以 丁酮 为溶剂， 以80%的产率得到
  参考文献：
  名称：

  HEMI (L)-TARTRATE FORMS OF 3-({5-CHLORO-1-[3-(METHYLSULFONYL)PROPYL]-1H-INDOL-2-YL}METHYL)-1-(2,2,2-TRIFLUOROETHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

  摘要：

  The present invention relates to hemi (L)-tartrate forms of the RSV fusion inhibitor 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (also known under its INN as rilematovir), and to processes for preparing said forms and the use of these forms in a pharmaceutical composition.

  公开号：

  US20210387984A1

文献信息

• [EN] HEMI (L)-TARTRATE FORMS OF 3-({5-CHLORO-1-[3-(METHYLSULFONYL)PROPYL]-1H-INDOL-2 YL} METHYL)-1-(2,2,2-TRIFLUOROETHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME<br/>[FR] FORMES D'HÉMI-(L)-TARTRATE DE 3-({5-CHLORO-1-[3-(MÉTHYLSULFONYL)PROPYL]-1 H-INDOL-2 YL}MÉTHYL)-1-(2,2,2-TRIFLUOROÉTHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE ET COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT
  申请人：JANSSEN SCIENCES IRELAND UNLIMITED CO

  公开号：WO2021250180A1

  公开（公告）日：2021-12-16

  The present invention relates to hemi (L)-tartrate forms of the RSV fusion inhibitor 3-(5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H- imidazo[4,5-c]pyridin-2-one (also known under its INN as rilematovir), and to processes for preparing said forms and the use of these forms in a pharmaceutical composition.