7-phenyl-1H-indazole | 141037-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 7-phenyl-1H-indazole
• CAS: 141037-88-9
• 化学式: C₁₃H₁₀N₂
• 分子量: 194.236
• InChiKey: UJIXVUOVVGDZGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-phenyl-1H-indazole 、 对甲苯磺酰氯 以 吡啶 为溶剂， 反应 2.5h， 以46%的产率得到1-tosyl-7-phenyl-1H-indazole
  参考文献：
  名称：

  Electrochemical Formation of Indazoles from Tropone Tosylhydrazones: Electrochemical Oxidations of Sodium Salts of Tosylhydrazones of Tropone and 2-Phenyltropone

  摘要：

  Electrochemical oxidations of the sodium salts of tropone and 2-phenyltropone tosylhydrazones afforded 2-tosyl-2H-indazole and 1-tosyl-7-phenyl-1H-indazole, respectively. The reactions proceeded through the cyclizations of the corresponding hydrazyl radicals generated by electrochemical one electron oxidations of the hydrazone anions.

  DOI：

  10.3987/com-91-5904
• 作为产物：
  描述：

  2-苯基环己酮 在 palladium on activated charcoal 乙醇 、 sodium 、 一水合肼 作用下， 以 甲醇 、 乙醚 、 萘烷 为溶剂， 反应 48.5h， 生成 7-phenyl-1H-indazole
  参考文献：
  名称：

  Electrochemical Formation of Indazoles from Tropone Tosylhydrazones: Electrochemical Oxidations of Sodium Salts of Tosylhydrazones of Tropone and 2-Phenyltropone

  摘要：

  Electrochemical oxidations of the sodium salts of tropone and 2-phenyltropone tosylhydrazones afforded 2-tosyl-2H-indazole and 1-tosyl-7-phenyl-1H-indazole, respectively. The reactions proceeded through the cyclizations of the corresponding hydrazyl radicals generated by electrochemical one electron oxidations of the hydrazone anions.

  DOI：

  10.3987/com-91-5904

文献信息

• INDAZOLE DERIVATIVES AS CRF ANTAGONISTS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1569911B1

  公开（公告）日：2008-07-02
• Electrochemical Formation of Indazoles from Tropone Tosylhydrazones: Electrochemical Oxidations of Sodium Salts of Tosylhydrazones of Tropone and 2-Phenyltropone
  作者：Katsuhiro Saito、Masashi Hattori、Tatsuji Sato、Kensuke Takahashi

  DOI：10.3987/com-91-5904

  日期：——

  Electrochemical oxidations of the sodium salts of tropone and 2-phenyltropone tosylhydrazones afforded 2-tosyl-2H-indazole and 1-tosyl-7-phenyl-1H-indazole, respectively. The reactions proceeded through the cyclizations of the corresponding hydrazyl radicals generated by electrochemical one electron oxidations of the hydrazone anions.