N'-(4-oxo-2-phenyl-3(4H)-quinazolinyl)-N-(2,4,6-trimethylphenyl)acetamidine hydrochloride | 1242245-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N'-(4-oxo-2-phenyl-3(4H)-quinazolinyl)-N-(2,4,6-trimethylphenyl)acetamidine hydrochloride
• CAS: 1242245-98-2
• 化学式: C₂₅H₂₄N₄O*ClH
• 分子量: 432.953
• InChiKey: GXQZARWHRAMJJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  31.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  59.28
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  3-氨基-2-苯基-4(3H)-喹唑啉酮 在 溶剂黄146 作用下， 反应 5.0h， 生成 N'-(4-oxo-2-phenyl-3(4H)-quinazolinyl)-N-(2,4,6-trimethylphenyl)acetamidine hydrochloride
  参考文献：
  名称：

  A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines

  摘要：

  A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures' determination of the synthesized compounds was carried out using spectroscopic techniques including IR, (1)H NMR, and mass spectrometry. Structural effects on reactivity were also studied. (C) 2010 Rasool Khan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.04.009