| 1039665-01-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• CAS: 1039665-01-4
• 化学式: C₁₂H₁₅N₃O₄
• 分子量: 265.269
• InChiKey: CSBGQCNEFDYPHN-LPEHRKFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.78
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  110.6
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  (2R,3S,5R)-5-(4-amino-1-methylpyrimidin-2-on-5-ylethynyl)-2-(4,4'-dimethyltrityloxymethyl)-3-hydroxytetrahydrofuran 在 盐酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 0.5h， 以68%的产率得到
  参考文献：
  名称：

  Artificial DNA Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases

  摘要：

  We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the beta-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.

  DOI：

  10.1021/ja801058h