1-Pentyl-3-piperidein | 53385-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Pentyl-3-piperidein
• 英文别名: 1-pentyl-1,2,3,6-tetrahydro-pyridine；1-pentyl-3,6-dihydro-2H-pyridine
• CAS: 53385-80-1
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: KLCFXPKQAICDSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Trisubstituted heterocyclic compounds and their use as fungicides
  申请人：Bayer CropScience S.A.

  公开号：EP1275301A1

  公开（公告）日：2003-01-15

  Compounds of general formula (I): in which: Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted in an adjacent manner with -P-Q1-T-Q2, -GZ and Y, such that the substituant -GZ is adjacent to both. the other substituants being as defined in the description, process for preparing these compounds, fungicidal compositions comprising these compounds, processes for treating plants by applying these compounds or compositions.

  通式（I）的化合物：其中：Het代表含有N、O、S等一到六个杂原子的五元或六元饱和、部分不饱和或芳香环，其中杂环以-P-Q1-T-Q2，-GZ和Y的相邻方式取代，使得取代基-GZ与其他取代基均相邻。其他取代基如描述中所定义，制备这些化合物的方法，包含这些化合物的杀真菌组合物，通过应用这些化合物或组合物处理植物的方法。
• Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-beta 1
  申请人：——

  公开号：US20040157868A1

  公开（公告）日：2004-08-12

  The invention relates to the use of a compound of formula (I): 1 for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-&bgr;1.

  本发明涉及使用公式（I）的化合物制备药物组合物以增加TGF-β1的循环、细胞和细胞外水平。
• Use of 4-substituted tetrahydropyridines for the manufacture of medicament s acting upon TGF-beta 1
  申请人：——

  公开号：US20020091143A1

  公开（公告）日：2002-07-11

  The invention relates to the use of a compound of formula (I): 1 for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-&bgr;1.

  本发明涉及使用式(I)的化合物制备药物组合物，用于增加循环、细胞和细胞外基质中TGF-&bgr;1的水平。
• Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
  申请人：Baroni Marco

  公开号：US20050222187A1

  公开（公告）日：2005-10-06

  The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.

  该发明涉及使用公式化合物制备治疗神经和脑部疾病的药物。该发明还涉及公式化合物的制备方法以及含有它们的药物组合物。
• FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT
  申请人：Seko Takuya

  公开号：US20080261947A1

  公开（公告）日：2008-10-23

  Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.

  式（I）所表示的融合吡嗪衍生物或其药学上可接受的盐（其中每个符号的含义如规范中所定义）。由于抑制了聚(ADP-核糖)聚合酶，式（I）所表示的化合物可用作预防和/或治疗各种缺血性疾病（在大脑、脊髓、心脏、消化道、骨骼肌、视网膜等部位），炎症性疾病（炎症性肠病、多发性硬化症、关节炎等），神经退行性疾病（锥体外系障碍、阿尔茨海默病、肌萎缩症、腰椎管狭窄等），糖尿病、休克、头部创伤、肾功能衰竭、高痛感等。此外，这些化合物还可用作抗逆转录病毒剂（HIV等）、治疗癌症的增敏剂和免疫抑制剂。