9-Aminopyrrolo[1,2-a][1,8]naphthyridine-8-carbonitrile | 1284237-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 9-Aminopyrrolo[1,2-a][1,8]naphthyridine-8-carbonitrile
• 英文别名: 9-aminopyrrolo[1,2-a][1,8]naphthyridine-8-carbonitrile
• CAS: 1284237-40-6
• 化学式: C₁₂H₈N₄
• 分子量: 208.222
• InChiKey: TYBBQEFKBCPJIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙二腈 、 [1,8]萘啶-2-甲醛 在 二氢吡啶 、 哌啶乙酸盐 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以53%的产率得到9-Aminopyrrolo[1,2-a][1,8]naphthyridine-8-carbonitrile
  参考文献：
  名称：

  One-pot multistep synthesis of 3-aminoindolizine derivatives

  摘要：

  We have developed an efficient one-pot multistep sequence to the synthesis of 3-aminoindolizine derivatives by using Hantzsch ester (9) as a mild hydride transfer agent. The reaction scope was investigated and the effect of substrates on reaction outcomes was discussed. (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2011.01.087

文献信息

• OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST
  申请人：L'OREAL

  公开号：US20160136077A1

  公开（公告）日：2016-05-19

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one aminobenzimidazole oxidation base of formula (I) in which the radicals R1 to R5 represent, independently of each other, a hydrogen atom; a halogen atom; a C1-C6 alkyl radical; a C1-C6 alkoxy radical; a C1-C6 dialkylamino radical; a carboxylic radical (—COOH); a sulfonic radical (—S03H); a phenyl radical; a sat orated or unsaturated 5- to 7-membered heterocyclic radical, comprising one or more heteroatoms chosen from N, O and S.
• [EN] OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST<br/>[FR] PROCÉDÉ DE COLORATION PAR OXYDATION À L'AIDE D'UNE COMPOSITION COMPRENANT UNE BASE D'OXYDATION AMINOBENZIMIDAZOLONE ET UN CATALYSEUR MÉTALLIQUE
  申请人：OREAL

  公开号：WO2014202792A2

  公开（公告）日：2014-12-24

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising : - one or more oxidizing agents, and - at least one aminobenzimidazole oxidation base of formula (I) in which the radicals R1 to R5 represent, independently of each other, a hydrogen atom; a halogen atom; a C1-C6 alkyl radical; a C1-C6 alkoxy radical; a C1-C6 dialkylamino radical; a carboxylic radical (- COOH); a sulfonic radical (-S03H); a phenyl radical; a saturated or unsaturated 5- to 7-membered heterocyclic radical, comprising one or more heteroatoms chosen from N, O and S.
• One-pot multistep synthesis of 3-aminoindolizine derivatives
  作者：Lianhai Li、Waepril Kimberly S. Chua

  DOI：10.1016/j.tetlet.2011.01.087

  日期：2011.3

  We have developed an efficient one-pot multistep sequence to the synthesis of 3-aminoindolizine derivatives by using Hantzsch ester (9) as a mild hydride transfer agent. The reaction scope was investigated and the effect of substrates on reaction outcomes was discussed. (C) 2011 Published by Elsevier Ltd.