5-(4-chloro-phenyl)-3-methyl-pyridin-2-ylamine | 930121-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(4-chloro-phenyl)-3-methyl-pyridin-2-ylamine
• 英文别名: 5-(4-chlorophenyl)-3-methylpyridin-2-amine
• CAS: 930121-88-3
• 化学式: C₁₂H₁₁ClN₂
• 分子量: 218.686
• InChiKey: STZXSQLBHPLHHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-3-甲基-5-溴吡啶 、 4-氯苯硼酸 以Obtained as an off-white solid (3.86 g, 83%)的产率得到5-(4-chloro-phenyl)-3-methyl-pyridin-2-ylamine
  参考文献：
  名称：

  Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists

  摘要：

  本发明涉及式（I）化合物，其中A、E、G、J、L、M、R1、R2和R3如规范和要求中所定义。本发明还涉及含有这种化合物的药物组合物以及制备这种化合物和组合物的方法。这些化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种中枢神经系统疾病。

  公开号：

  US08349844B2

文献信息

• Novel compounds as metabotropic glutamate receptor antagonists
  申请人：McArthur Gatti Silvia

  公开号：US20070072879A1

  公开（公告）日：2007-03-29

  The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R 1 , R 2 , and R 3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.

  本发明涉及具有以下结构的化合物（I）其中A、E、G、J、L、M、R1、R2和R3如规范和索赔中所定义。该发明还涉及含有这种化合物的药物组合物以及制备这些化合物和组合物的方法。这些化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种中枢神经系统疾病。
• Novel Processes for the manufacture of Propane-1-sulfonic acid -amide
  申请人：Brumsted Corey James

  公开号：US20120022258A1

  公开（公告）日：2012-01-26

  According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as intermediates and novel synthesis routes for key intermediates used in those processes.

  根据本发明提供了制备化合物1的新工艺，以及用于这些工艺中的中间体和关键中间体的新合成路线。
• NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID (3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-b]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL)-AMIDE
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20160083378A1

  公开（公告）日：2016-03-24

  According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as intermediates and novel synthesis routes for key intermediates used in those processes.

  根据本发明，提供了制造式1化合物的新工艺，以及用于这些工艺中使用的中间体和关键中间体的新合成路线。
• Compounds as metabotropic glutamate receptor antagonists
  申请人：Hoffmann-La Roche Inc.

  公开号：US07504404B2

  公开（公告）日：2009-03-17

  The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.

  本发明涉及式（I）的化合物，其中A、E、G、J、L、M、R1、R2和R3如说明书和权利要求所定义。本发明还涉及含有这种化合物的制药组合物和制备这种化合物及组合物的方法。这些化合物是代谢型谷氨酸受体拮抗剂，可用于治疗多种中枢神经系统疾病。
• SUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS
  申请人：Gatti McArthur Silvia

  公开号：US20120041002A1

  公开（公告）日：2012-02-16

  The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R 1 , R 2 , and R 3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.

  本发明涉及式（I）的化合物，其中A，E，G，J，L，M，R1，R2和R3如规范和权利要求中所定义。该发明还涉及含有这种化合物的药物组合物以及制备这种化合物和组合物的方法。这些化合物是代谢型谷氨酸受体拮抗剂，可用于治疗多种中枢神经系统疾病。