| 1242182-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• CAS: 1242182-25-7
• 化学式: C₃₆H₄₈N₆O₁₂
• 分子量: 756.81
• InChiKey: MFJIJMPWAHMEPW-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 三氟乙酸 以 二氯甲烷 为溶剂， 以92%的产率得到
  参考文献：
  名称：

  Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription

  摘要：

  We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.080
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 6,13,20-Tris(aminomethyl)-22,23,24-trioxa-3,10,17-triazatetracyclo[17.2.1.15,8.112,15]tetracosa-1(21),5,7,12,14,19-hexaene-2,9,16-trione 以 甲醇 、 乙酸乙酯 为溶剂， 以423 mg的产率得到
  参考文献：
  名称：

  Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription

  摘要：

  We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.080