6-(diethylamino)methyl-2-aminopyridine | 400774-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(diethylamino)methyl-2-aminopyridine
• 英文别名: 2-Amino-6-N,N-diethylaminomethylpyridine；6-(Diethylaminomethyl)pyridin-2-amine
• CAS: 400774-98-3
• 化学式: C₁₀H₁₇N₃
• 分子量: 179.265
• InChiKey: FARHILJDMZTKIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(diethylamino)methyl-2-aminopyridine 在 正丁基锂 、 三乙胺 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  PHOSPHO-AMINO PINCER-TYPE LIGANDS AND CATALYTIC METAL COMPLEXES THEREOF

  摘要：

  本发明提供了磷酸氨基夹持型配体、其金属配合物以及包括这种金属配合物的催化方法。

  公开号：

  US20120323007A1
• 作为产物：
  描述：

  6-溴吡啶-2-甲醛 在 copper(I) oxide 、 氨 、 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 、 乙二醇 为溶剂， -30.0~110.0 ℃ 、1.01 MPa 条件下， 反应 26.0h， 生成 6-(diethylamino)methyl-2-aminopyridine
  参考文献：
  名称：

  Ethylene polymerization by PN3-type pincer chromium(III) complexes

  摘要：

  Chromium (III) complexes, Cr1, [2,6-((Bu2PNH)-Bu-t)(2)C5H4N]CrCl3; Cr2, [2,6-(Ph2PNH)(2)C5H4N]CrCl3; Cr3, [2-((Bu2PNH)-Bu-t)C5H4N]CrCl3 THF; Cr4, [6-((Bu2PNH)-Bu-t)C5H4N-2-CH2NEt2]CrCl3; Cr5, [6-((Bu2PNH)-Bu-t)C5H4N-2-C3H2N2]CrCl3; Cr6, [6-((Bu2PNH)-Bu-t)C5H4N-2-(3,5-Me-2)C3H2N2]CrCl3; Cr7, [6-((Bu2PNH)-Bu-t)C5H4N-2-(3,5-iPr(2))C-3 H2N2]CrCl3; Cr8, [6-((Bu2PNH)-Bu-t)C5H4N-2-(3,5-Ph-2)C3H2N2]CrCl3, bearing a family of neutral PN3-type pincer ligands have been prepared. The molecular structure of Cr2 was further elucidated by the X-ray crystallographic analysis, showing an octahedral geometry. Treatment of these complexes with MAO or alkylaluminum led to catalysts with moderate activities (about 10(5) g (PE)/Cr(mol)h) for ethylene polymerization, affording exclusively linear low molecular weight solid PE without any detectable oligomers. Among Cr1-Cr8, the highest activity was achieved for Cr1/MAO at room temperature with production of PE with highest molecular weight, indicating that replacement of both Bu-t groups in Cr1 with Ph groups, or one (PBu2)-Bu-t with the N (imine) arm, resulted in a lower catalytic activity and lower M-w. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2014.08.005

文献信息

• BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE
  申请人：Jung Seung Hyun

  公开号：US20120302567A1

  公开（公告）日：2012-11-29

  The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.

  本发明涉及一种新颖的双环杂环芳基衍生物，其药用盐，水合物和溶剂合物，具有改进的蛋白激酶抑制活性，并且包括作为活性成分的药物组合物，用于预防或治疗异常细胞生长紊乱。
• Thiazolyl urea compounds and methods of uses
  申请人：——

  公开号：US20020193405A1

  公开（公告）日：2002-12-19

  Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的新型尿素化合物对预防和治疗疾病有效，如细胞增殖或凋亡介导的疾病。该发明涵盖了新型化合物、类似物、前药和其药用可接受的盐，以及用于预防和治疗中风、癌症等疾病和其他疾病或病况的药物组合物和方法。该发明还涉及制备此类化合物的方法，以及在这些过程中有用的中间体。
• Urea compounds and methods of uses
  申请人：——

  公开号：US20020173507A1

  公开（公告）日：2002-11-21

  Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选择的新型尿素化合物对预防和治疗疾病有效，例如细胞增殖或凋亡介导的疾病。该发明涵盖了新型化合物、类似物、前药和其药用可接受的盐、预防和治疗涉及中风、癌症等疾病和其他疾病或病症的药物组合物和方法。该发明还涉及制备此类化合物的过程以及在此类过程中有用的中间体。
• [EN] THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSES DE THIAZOLYL UREE POUR LE TRAITEMENT DU CANCER
  申请人：AMGEN INC

  公开号：WO2003070727A1

  公开（公告）日：2003-08-28

  Selected thiazolyl urea compounds of formula (VI) are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  公式（VI）的选定噻唑基脲类化合物对预防和治疗细胞增殖或凋亡介导的疾病有效。本发明涵盖新的化合物、类似物、前药和其药学上可接受的盐、药物组合物和预防和治疗中风、癌症等疾病及其他疾病或情况的方法。本发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• Urea compounds as kinase inhibitors
  申请人：Amgen, Inc.

  公开号：EP1619184A2

  公开（公告）日：2006-01-25

  Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  精选的新型脲化合物可有效预防和治疗疾病，如细胞增殖或凋亡介导的疾病。本发明包括新型化合物、类似物、原药及其药学上可接受的盐、药物组合物以及用于预防和治疗涉及中风、癌症等疾病和其他弊病或病症的方法。本发明还涉及制造此类化合物的工艺以及在此类工艺中有用的中间体。