5-Bromo-2-(difluoromethyl)-3-fluoropyridine | 1806770-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Bromo-2-(difluoromethyl)-3-fluoropyridine
• CAS: 1806770-23-9
• 化学式: C₆H₃BrF₃N
• 分子量: 225.99
• InChiKey: SWEPDKQKBBIAFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE INHIBANT EIF4E
  申请人：EFFECTOR THERAPEUTICS INC

  公开号：WO2021003157A1

  公开（公告）日：2021-01-07

  The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

  本发明提供了根据式I合成的化合物、药用可接受的配方和用途，或其立体异构体、互变异构体或药用可接受的盐。对于式I化合物，X1、X2、X3、X4、X5、X6、Q、L1、L2、Y、R1、R2、R3、R4、R5、R6、R7、R8和环A、B和C的定义如规范中所述。创新的式I化合物是eIF4e的抑制剂，并在许多治疗应用中发挥作用，包括但不限于治疗炎症和各种癌症。
• NOVEL PYRIDAZINES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210024495A1

  公开（公告）日：2021-01-28

  The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.

  本发明涉及新颖的吡啶嗪，其制备方法，含有它们的药物组合物以及它们在治疗中的应用，特别是在通过Autotaxin介导的疾病和障碍的治疗和/或预防中的应用。
• N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
  申请人：Boehringer Ingelheim International GmbH

  公开号：US11485727B2

  公开（公告）日：2022-11-01

  The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by autotaxin.

  本发明涉及新型哒嗪类化合物、其制备工艺、含有它们的药物组合物及其在治疗中的用途，特别是在治疗和/或预防由自体表皮生长因子介导的疾病和失调中的用途。
• EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS
  申请人：Effector Therapeutics Inc.

  公开号：EP3994139A1

  公开（公告）日：2022-05-11
• N-METHYL, N-(6-(METHOXY)PYRIDAZIN-3-YL) AMINE DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATORY AIRWAY OR FIBROTIC DISEASES
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP4003998A1

  公开（公告）日：2022-06-01