4-哌嗪基甲基苯酚 | 75341-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-哌嗪基甲基苯酚
• 英文名称: 4-OH-BZP
• 英文别名: 4-OH benzylpiperazine；p-Hydroxybenzylpiperazine；4-(piperazin-1-ylmethyl)phenol
• CAS: 75341-33-2
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: CNRXJITXJZQWPJ-UHFFFAOYSA-N

物化性质

• 沸点：
  336.4±27.0 °C(Predicted)
• 密度：
  1.129±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-哌嗪基甲基苯酚 、 1,4-bis-(4-hydroxy-benzyl)-piperazine 生成 4-((Methyl(phenethyl)amino)methyl)phenol
  参考文献：
  名称：

  Cationic effect-driven carbinol/amine reaction

  摘要：

  芳基和杂环甲胺可以通过在阳离子效应试剂存在下将羟基芳基甲醇或杂环甲醇与一级或二级胺反应制备。

  公开号：

  US05142052A1

文献信息

• IL-17 Ligands And Uses Thereof
  申请人：DICE Molecules SV LLC.

  公开号：US20200247785A1

  公开（公告）日：2020-08-06

  Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.

  本文提供了新型配体及其药物组合物，可调节IL-17A。还提供了制备IL-17A调节剂的方法。这些化合物可能在治疗和/或预防炎症、癌症或自身免疫疾病等方面有用。
• SUPRAMOLECULAR HANDCUFFS IN POLYMERIC ARCHITECTURE
  申请人：Rauwald Urs

  公开号：US20100247477A1

  公开（公告）日：2010-09-30

  This invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, wherein the first and second CB[8] guest molecules form a ternary host-guest complex with a CB[8] molecule which non-covalently links the polymeric molecule and the attachment compound in a supramolecular polymer. These polymers are useful as vehicles for delivery of a therapeutic compound for use in a method of treatment of the human or animal body, in particular for use in a method of delivering the therapeutic compound to a target site in an individual. The invention also provides methods for the preparation of the supramolecular polymers.

  这项发明涉及一般的超分子聚合物，包括将聚合物分子与第一个CB[8]宾主分子连接，并将附着化合物与第二个CB[8]宾主分子连接，其中第一个和第二个CB[8]宾主分子与CB[8]分子形成三元宿主-客体复合物，CB[8]分子非共价地连接聚合物分子和附着化合物形成超分子聚合物。这些聚合物可用作传递治疗化合物的载体，用于治疗人体或动物体的方法，特别是用于将治疗化合物传递到个体的靶位点的方法。该发明还提供了制备超分子聚合物的方法。
• BENZOTHIOPHENE ALKANOL PIPERAZINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSANT
  申请人：Li Jianqi

  公开号：US20110118263A1

  公开（公告）日：2011-05-19

  The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT, NA and DA. Compared with clinical used antidepressants so far having single target, e.g. desipramine and fluoxetine, and clinical used antidepressants so far having double targets, e.g venlafaxine and duloxetine, the said benzothiophene alkanol piperazine derivatives of the present invention may have a broader indication range and less toxic and side effects to nervous system. The benzothiophene alkanol piperazine derivatives are the compounds with the following formula or their pharmaceutically acceptable salts, wherein Ar 1 , R 1 -R 4 , X, Y, m and n have the same definition as defined in claim 1.

  该发明披露了苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁药物的用途。该发明揭示了所述苯并噻吩烷醇哌嗪衍生物对5-HT、NA和DA的再摄取具有三重抑制效应。与迄今为止具有单一靶点的临床使用抗抑郁药物（如去甲丙胺和氟西汀）以及迄今为止具有双重靶点的临床使用抗抑郁药物（如文拉法辛和度洛西汀）相比，本发明的苯并噻吩烷醇哌嗪衍生物可能具有更广泛的适应症范围，对神经系统的毒性和副作用更少。苯并噻吩烷醇哌嗪衍生物是具有以下结构式或其药用盐的化合物，其中Ar1、R1-R4、X、Y、m和n的定义与权利要求1中定义的相同。
• [EN] NOVEL AMINOMETHYL-PHENOL DERIVATIVES AS ANTIMALARIAL AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS D'AMINOMÉTHYLPHÉNOL EN TANT QU'AGENTS ANTIPALUDIQUES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2014072903A1

  公开（公告）日：2014-05-15

  The invention relates to novel aminomethyl-phenol derivatives of formula I wherein R1 to R4, X, A and B are as defined for formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.

  该发明涉及一种新的氨甲基酚衍生物，其化学式为I，其中R1至R4、X、A和B如化学式I所定义，并且其作为药物成分用于制备药物组合物。该发明还涉及相关方面，包括含有其中一种或多种化合物的药物组合物以及其作为药物治疗或预防原虫感染，尤其是疟疾的用途。
• Substituted piperazines,(1,4) diaszepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists
  申请人：Ancliff Rachel

  公开号：US20060025404A1

  公开（公告）日：2006-02-02

  The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

  本发明涉及具有药理活性的新型哌嗪和氮杂环庚烷衍生物，它们的制备方法，包含它们的组合物，以及它们在治疗包括阿尔茨海默病在内的神经退行性疾病中的应用。