3,3',4,4'-tetramethyl-5,5'-diphenyl-1,1'-(pentane-2,4-diyl)-2,2'-biphospholyl-P,P'-dichloropalladium(II) | 592517-24-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3',4,4'-tetramethyl-5,5'-diphenyl-1,1'-(pentane-2,4-diyl)-2,2'-biphospholyl-P,P'-dichloropalladium(II)
• CAS: 592517-24-3
• 化学式: C₂₉H₃₂P₂
• 分子量: 442.521
• InChiKey: OCUZDVJJGBJCRP-NUZOEIIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.42
• 重原子数：
  31.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  bis(acetonitrile)dichloroplatinum(II) 、 3,3',4,4'-tetramethyl-5,5'-diphenyl-1,1'-(pentane-2,4-diyl)-2,2'-biphospholyl-P,P'-dichloropalladium(II) 以 甲苯 为溶剂， 以92%的产率得到(-)-3,3',4,4'-tetramethyl-5,5'-diphenyl-1,1'-(pentane-2,4-diyl)-2,2'-biphospholyl-P,P'-dichloroplatinum(II)
  参考文献：
  名称：

  对映体纯的铂（II）与手性二膦和衍生自2,2-双磷的二亚膦酸酯配体的配合物：合成，晶体结构和催化

  摘要：

  摘要通过对映体的动态手性控制，通过手性立体动力学二膦和2,2-二磷酰基衍生的二亚膦酸酯配体合成了对映体纯铂（II）配合物。这些铂配合物的催化性能已经在不对称加氢甲酰化中得到了探索。在化学选择性和区域选择性方面，所有配合物均被证明是有效的催化剂，但仅诱导了低对映选择性。

  DOI：

  10.1016/j.ica.2007.09.043

文献信息

• Stereochemically Dynamic 2,2‘-Biphosphole Ligands for Asymmetric Catalysis
  作者：Emmanuel Robé、Carmen Ortega、Maciek Mikina、Marian Mikolajczyk、Jean-Claude Daran、Maryse Gouygou

  DOI：10.1021/om0503646

  日期：2005.11.1

  The stereochemically dynamic 2,2'-biphospholes 8, 9, and 10 have been synthesized by asymmetric alkylation of 2,2'-biphospholyl anion with enantiomerically pure diol ditosylates. A good carbon-to-phosphorus induction has been obtained in particular in the case of compound 8. The introduction of a chiral linker between the two phosphorus atoms resulted in partial chirality control of the central and axial chiralities of the 2,2'-biphosphole framework, as three diastereoisomers a, b, and c are obtained among the six expected. In solution at room temperature a, b, and c diastereoisomers exist as an equilibrium mixture; the interconversion occurred by phosphorus-inversion inducing atropoinversion. Reaction of the equilibrium mixture of 2,2'-biphosphole with [MCl2(CH3CN)(2)] resulted in dynamic resolution leading to diastereo- and enantiopure Pd- and Pt-complexes. Palladium-catalyzed asymmetric allylic substitution can be achieved with the ligands 8 and 10 with high activities but still moderate enantioselectivities.