1-methyl-4-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazol-3-amine | 1269440-86-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1-methyl-4-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazol-3-amine
• 英文别名: 1-Methyl-4-(2-methylsulfanylpyrimidin-4-yl)pyrazol-3-amine
• CAS: 1269440-86-9
• 化学式: C₉H₁₁N₅S
• 分子量: 221.286
• InChiKey: XEHFIEBYUHCURF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  94.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] DÉRIVÉ D'INDÉNONE ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2011030955A1

  公开（公告）日：2011-03-17

  An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

  式（1）的吲哚酮衍生物能够增强成骨细胞的活性，抑制破骨细胞的骨吸收作用，含有该吲哚酮衍生物或其药用盐的药用组合物可用于预防或治疗骨质疏松等骨病。
• [EN] COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS EN TANT QU'INHIBITEURS DE PROTÉINE KINASE
  申请人：IRM LLC

  公开号：WO2011025927A1

  公开（公告）日：2011-03-03

  The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

  这项发明提供了一类新型的化合物，其化学式为1，包括这些化合物的药物组合物以及使用这些化合物来治疗或预防与异常或失调的激酶活性相关的疾病或障碍的方法，特别是涉及B-Raf异常激活的疾病或障碍。
• COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
  申请人：Huang Shenlin

  公开号：US20110306625A1

  公开（公告）日：2011-12-15

  The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

  本发明提供了一类新型化合物，包括这些化合物的药物组成物，以及使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或疾病的方法，特别是涉及B-Raf异常活化的疾病或疾病的方法。
• Compounds and compositions as protein kinase inhibitors
  申请人：Array BioPharma, Inc.

  公开号：US10005761B2

  公开（公告）日：2018-06-26

  The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

  本发明提供了一类新型化合物、包含此类化合物的药物组合物以及使用此类化合物治疗或预防与激酶活性异常或失调有关的疾病或紊乱的方法，特别是涉及 B-Raf 异常活化的疾病或紊乱。
• INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Korea Research Institute Of Chemical Technology

  公开号：EP2475649A1

  公开（公告）日：2012-07-18