5-chloro-2-diethylamino-3-formyl-2H-indazole | 318276-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-chloro-2-diethylamino-3-formyl-2H-indazole
• 英文别名: 5-Chloro-2-(diethylamino)indazole-3-carbaldehyde
• CAS: 318276-81-2
• 化学式: C₁₂H₁₄ClN₃O
• 分子量: 251.716
• InChiKey: CDEKMBINMTUIRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-chloro-2-diethylamino-3-formyl-2H-indazole 在 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 6-氯噌啉
  参考文献：
  名称：

  Two Unusual, Competitive Mechanisms for (2-Ethynylphenyl)triazene Cyclization:  Pseudocoarctate versus Pericyclic Reactivity

  摘要：

  The cyclization of (2-ethynylphenyl)triazenes in ODCB at 200 degrees C gives exclusively cinnolines, whereas addition of CuCl to 1,2-dichloroethane solutions of the triazenes at 50 degrees C results in the sole formation of isoindazoles. DFT calculations and deuterium labeling studies suggest the intermediacy of a 3-dehydrocinnolinium ion, produced through a pericyclic transition state. Calculations and trapping studies strongly implicate a carbene intermediate in isoindazole formation, which proceeds through a pseudocoarctate transition state.

  DOI：

  10.1021/ja017227u
• 作为产物：
  描述：

  4-Chloro-2-iodobenzenediazonium 在 吡啶 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 对甲苯亚磺酸 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 水 、 二甲基亚砜 、 三乙胺 、 乙腈 为溶剂， 反应 34.33h， 生成 5-chloro-2-diethylamino-3-formyl-2H-indazole
  参考文献：
  名称：

  光化学或热化学无金属合成 2H-吲唑骨架

  摘要：

  开发了一种在无金属条件下简单且调谐的 2 H-吲唑骨架合成方法。在室温可见光照射下，2-((芳基/烷基/H)乙炔基))芳基三氮烯与芳基亚磺酸反应，通过电子供体-受体复合物产生3-官能化2H-吲唑，无需额外的光催化剂。在芳基亚磺酸存在下，2-(乙炔基)芳基三氮烯在空气中于 50 °C 下发生分子内氧化/环化，生成 2 H-吲唑-3-甲醛。

  DOI：

  10.1021/acs.joc.3c01091

文献信息

• Thermal Cyclization of (2-Ethynylphenyl)triazenes:  Facile Synthesis of Substituted Cinnolines and Isoindazoles
  作者：David B. Kimball、Austin G. Hayes、Michael M. Haley

  DOI：10.1021/ol006517x

  日期：2000.11.1

  [GRAPHICS]High-temperature intramolecular cyclization of N,N-dialkyl-N'-(4-substituted-2-ethynylphenyl)triazines provides under neutral conditions both 6-substituted cinnolines and 5-substituted isoindazoles in moderate to excellent yields.
• Cyclization of 1-(2-Alkynylphenyl)-3,3-dialkyltriazenes:  A Convenient, High-Yield Synthesis of Substituted Cinnolines and Isoindazoles
  作者：David B. Kimball、Timothy J. R. Weakley、Michael M. Haley

  DOI：10.1021/jo020229s

  日期：2002.9.1

  A new route to isoindazoles and cinnolines through the cyclization of (2-alkynylphenyl)triazenes under neutral conditions is presented. The products that result from heating the starting triazenes depend on both the type of alkyne ortho to the triazene functionality and the temperature used. Butadiyne moieties ortho to dialkyltriazenes yield bis-isoindazole dimers when heated to 150 degreesC in MeI. A requirement for cyclization in MeI is that the (2-alkynylphenyl)triazene must contain a suitably electron-withdrawing substituent on the phenyl ring to deactivate the triazene toward methylation-induced decomposition to an iodoarene. Ethynyl moieties ortho to dialkyltriazenes yield both isoindazole dimers as well as 3-formylisoindazoles when subjected to the same conditions. Replacing MeI with 1,2-dichlorobenzene as solvent allows for the general cyclization of (2-ethynylphenyl)dialkyltriazenes. Heating to 170 degreesC results in a mixture of isoindazole and cinnoline products, whereas the cinnolines are produced exclusively in high yield at 200 degreesC. Alternatively, the isoindazoles can be obtained in good to excellent yield by stirring a 1,2-dichloroethane solution of the starting triazene with CuCl overnight at 50 degreesC.