11-p-tolyl-undecanoic acid ethyl ester | 454686-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 11-p-tolyl-undecanoic acid ethyl ester
• 英文别名: 11-p-Tolyl-undecansaeure-aethylester；ethyl 11-(4-methylphenyl)undecanoate
• CAS: 454686-11-4
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: MBTQBZGSWPBOTD-UHFFFAOYSA-N

物化性质

• 沸点：
  230-235 °C(Press: 12 Torr)
• 密度：
  0.940±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.61
• 重原子数：
  22.0
• 可旋转键数：
  12.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  11-p-tolyl-undecanoic acid ethyl ester 在 氢氧化钾 、 oxonium 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以95%的产率得到11-(4-methylphenyl)undecanoic acid
  参考文献：
  名称：

  具有带有芳族单元的脂肪酸链的新型磷脂酰胆碱脂质的合成。氧化稳定的流体磷脂膜的产生

  摘要：

  已经合成了二酰基磷脂类似物的第一实例，该二酰基磷脂类似物在其烃链的各个深度处包含芳族单元。由这些新合成脂质的超声处理的水悬浮液制得的膜具有氧化稳定性，并具有较长的保存期限。这些膜在环境温度下保持流体特性，使其成为膜蛋白重构研究的理想选择。

  DOI：

  10.1016/s0040-4039(02)00758-x
• 作为产物：
  描述：

  10-十一烯酸乙酯 、 甲苯 在 三氯化铝 作用下， 生成 11-p-tolyl-undecanoic acid ethyl ester
  参考文献：
  名称：

  Elevated plasma free fatty acid concentrations do not modify cardiac repolarization in patients treated by electrolyte-glucose-insulin infusion

  摘要：

  Fat emulsion infusion is routinely used as a source of calories and essential fatty acids for critically ill patients who may be at risk for acquired ventricular repolarization alterations due either to drugs or electrolyte disturbances. The aim of this study was to evaluate whether acute elevations of plasma free fatty acid concentrations influence the corrected Q-T interval (Q-Tc), Q-Tc dispersion and sympathetic nervous system activity in patients requiring parenteral nutrition. Thirty hospitalized patients (mean+/-SD: 62 +/- 17 yr of age) requiring total parenteral nutrition received an infusion of 10% (500 ml) triacylglycerol emulsion as a source of calories (450 Kcal); on another occasion, and in random order, the same patients received an infusion of 20% (500 ml) triacylglycerol emulsion (900 Kcal). The infusion lasted 8 h and was preceded by a sc injection of heparin (5000 U). Infusions of both 10% and 20% triacylglycerol emulsion increased plasma free fatty acid (p<0.001) and triacylglycerol (p<0.01) concentrations, and was associated with no significant change in mean BP, heart rate, and plasma catecholamines. At baseline, Q-Tc and Q-Tc dispersion were within the normal range (<440 milliseconds for QTc and <40 ms for QTc-d) and did not show any significant change at any time during infusion of triacylglycerol emulsion at both concentrations. In the setting of a balanced parenteral nutrition, acute elevation of plasma free fatty acid concentrations in critically ill patients do not modify ventricular repolarization. (C) 2002, Editrice Kurtis.

  DOI：

  10.1007/bf03345073