9H-fluoren-9-ylmethyl N-(4-carbonochloridoylphenyl)-N-[(4-methoxyphenyl)methyl]carbamate | 925676-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl N-(4-carbonochloridoylphenyl)-N-[(4-methoxyphenyl)methyl]carbamate
• CAS: 925676-13-7
• 化学式: C₃₀H₂₄ClNO₄
• 分子量: 497.978
• InChiKey: HEYRAMXAEXSREQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9H-fluoren-9-ylmethyl N-(4-carbonochloridoylphenyl)-N-[(4-methoxyphenyl)methyl]carbamate 在 氯化亚砜 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.0h， 生成 {4-[(4-Chlorocarbonyl-phenyl)-(4-methoxy-benzyl)-carbamoyl]-phenyl}-(4-methoxy-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligo(p-benzamide) Foldamers

  摘要：

  A coupling protocol has been developed which allows the synthesis of oligo(p-benzamide)s on solid support. Aromatic carboxylic acids are activated in situ with thionyl chloride and used to acylate secondary aromatic amines. N-p-Methoxy benzyl (PMB) as well as N-hexyl protected monomers were investigated. Heterosequences of both monomers were synthesized. Such nanoscale objects are important building blocks for supramolecular chemistry.

  DOI：

  10.1021/ol0603357
• 作为产物：
  描述：

  N,N-9-fluorenylmethyloxycarbonyl-(4-methoxybenzyl)-4-aminobenzoic acid 在 氯化亚砜 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.0h， 生成 9H-fluoren-9-ylmethyl N-(4-carbonochloridoylphenyl)-N-[(4-methoxyphenyl)methyl]carbamate
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligo(p-benzamide) Foldamers

  摘要：

  A coupling protocol has been developed which allows the synthesis of oligo(p-benzamide)s on solid support. Aromatic carboxylic acids are activated in situ with thionyl chloride and used to acylate secondary aromatic amines. N-p-Methoxy benzyl (PMB) as well as N-hexyl protected monomers were investigated. Heterosequences of both monomers were synthesized. Such nanoscale objects are important building blocks for supramolecular chemistry.

  DOI：

  10.1021/ol0603357