2-氯-6-羟基喹唑啉-4(3H)-酮 | 591245-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-氯-6-羟基喹唑啉-4(3H)-酮
• 英文名称: 2-chloro-6-hydroxy-3H-quinazolin-4-one
• 英文别名: 2-Chloro-6-hydroxyquinazolin-4(3H)-one
• CAS: 591245-00-0
• 化学式: C₈H₅ClN₂O₂
• 分子量: 196.593
• InChiKey: VFLRMJSHSQGSFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  四氢吡咯 、 2-氯-6-羟基喹唑啉-4(3H)-酮 以 乙醇 为溶剂， 以79%的产率得到6-Hydroxy-2-pyrrolidin-1-yl-3H-quinazolin-4-one
  参考文献：
  名称：

  Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones☆

  摘要：

  A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00142-1
• 作为产物：
  描述：

  6-acetoxy-2,4-dichloroquinazoline 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 3.0h， 以82%的产率得到2-氯-6-羟基喹唑啉-4(3H)-酮
  参考文献：
  名称：

  Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones☆

  摘要：

  A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00142-1