N,N'-((1R,2R)-1,2-diphenylethane-1,2-diyl)dibenzamide | 87671-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-((1R,2R)-1,2-diphenylethane-1,2-diyl)dibenzamide
• 英文别名: racem.-N,N'-bibenzyl-α,α'-diyl-bis-benzamide；racem.-N,N'-Bibenzyl-α,α'-diyl-bis-benzamid；racem. N.N'-Dibenzoyl-α.α'-diphenyl-aethylendiamin；racem-N,N'-Bibenzyl-α,α'-diyl-bis-benzamid；N,N'-Dibenzoyl-α.α'-diphenyl-aethylendiamin；(1R,2R)-N1,N2-dibenzoyl-1,2-diphenylethylenediamine；(1R,2R)-N¹,N²-dibenzoyl-1,2-diphenylethylenediamine
• CAS: 87671-32-7；87671-33-8；503839-90-5
• 化学式: C₂₈H₂₄N₂O₂
• 分子量: 420.511
• InChiKey: QUYGZYLIDVTSQA-CLJLJLNGSA-N

物化性质

• 沸点：
  714.1±60.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.33
• 重原子数：
  32.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.2
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N,N'-((1R,2R)-1,2-diphenylethane-1,2-diyl)dibenzamide 在 盐酸 作用下， 生成 (+)-(4R,5R)-4,5-dihydro-2,4,5-triphenyl-1H-imidazole
  参考文献：
  名称：

  Feist; Arnstein, Chemische Berichte, 1895, vol. 28, p. 3172

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 N,N'-((1R,2R)-1,2-diphenylethane-1,2-diyl)dibenzamide
  参考文献：
  名称：

  Feist; Arnstein, Chemische Berichte, 1895, vol. 28, p. 3172

  摘要：

  DOI：

文献信息

• One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
  作者：Vjekoslav Štrukil、Boris Bartolec、Tomislav Portada、Ivica Đilović、Ivan Halasz、Davor Margetić

  DOI：10.1039/c2cc36613d

  日期：——

  Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.

  通过机械化学碳二亚胺介导的羧酸和胺的偶联，描述了环境友好的一锅合成酰胺，双酰胺和二肽。高反应产率和简单的水后处理使得可以从容易获得的试剂中清洁，实用，快速地制备各种含有酰胺键的化合物。
• Elimination of benzotriazolyl group in N-(α-benzotriazol-1-ylalkyl)amides and N-(α-benzotriazol-1-ylalkyl)sulfonamides: their self-coupling and cross-coupling reactions with carbonyl compounds
  作者：Xiaoxia Wang、Yongjun Liu、Yongmin Zhang

  DOI：10.1016/j.tet.2003.08.039

  日期：2003.10

  The elimination of benzotriazolyl group from N-(α-benzotriazol-1-ylalkyl)amides and N-(α-benzotriazol-1-ylalkyl)sulfonamides are readily realized with samarium diiodide as a reducing agent. The resulting intermediates undergo a dimerization or cross-coupling reaction with carbonyl compounds, thus affording the corresponding dimers or α-hydroxyalkylated sulfonamides in moderate yields.

  用二碘化sa作为还原剂容易地从N-（α-苯并三唑-1-基烷基）酰胺和N-（α-苯并三唑-1-基烷基）磺酰胺中消除苯并三唑基。所得中间体与羰基化合物进行二聚或交叉偶联反应，从而以中等收率得到相应的二聚体或α-羟烷基化磺酰胺。
• Reactivity of AllylSmBr/HMPA: Facile Synthesis of 3-Aryl-1,2,4-benzotriazines
  作者：Ruifeng Yin、Liejin Zhou、Huili Liu、Hui Mao、Xin Lü、Xiaoxia Wang

  DOI：10.1002/cjoc.201200989

  日期：2013.1

  3‐Aryl‐1,2,4‐benzotriazines were conveniently prepared in moderate to good yields from 1,l‐bis(benzotriazol‐1‐yl)methylarenes with allylsamarium bromide/hexamethylphosphramide (allylSmBr/HMPA). Preliminary results indicate that HMPA may enhance the reducing ability as well as prohibit the nucleophicility of allylSmBr, thus making allylSmBr/HMPA as a promising single‐electron transfer (SET) reagent

  由1，l-双（苯并三唑-1-基）甲基芳烃与烯丙基溴化//六甲基磷酰胺（allylSmBr / HMPA）制备中度到良好收率的3-芳基1,2,4-苯并三嗪很方便。初步结果表明，HMPA可能增强烯丙基SmBr的还原能力，并阻止其烯键性，因此使烯丙基SmBr / HMPA成为有前途的单电子转移（SET）试剂。
• Japp; Moir, Journal of the Chemical Society, 1900, vol. 77, p. 640
  作者：Japp、Moir

  DOI：——

  日期：——
• Hayashi, Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1941, vol. 39, p. 107,112
  作者：Hayashi

  DOI：——

  日期：——