3,4-Dihydro-5H-2,3-benzodiazepin | 90557-27-0

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 3,4-Dihydro-5H-2,3-benzodiazepin
• 英文别名: 4,5-dihydro-3H-benzo[d][1,2]diazepine；4,5-dihydro-3H-2,3-benzodiazepine
• CAS: 90557-27-0
• 化学式: C₉H₁₀N₂
• 分子量: 146.192
• InChiKey: ZOIDJSXQPWPCDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 2,3-BENZODIAZEPINES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150203483A1

  公开（公告）日：2015-07-23

  What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I) in which R 1a , R 1b , R 1c , R 2 , R 3 , R 4 , R 5 , A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.

  所描述的是一般式(I)的BET蛋白抑制剂，特别是BRD4抑制剂2,3-苯二氮䓬类化合物，其中R1a、R1b、R1c、R2、R3、R4、R5、A和X的含义如描述所示，用于制备本发明化合物的中间体，包括本发明化合物的药物组合物以及它们在高增殖性疾病，特别是肿瘤疾病的预防和治疗中的用途。还描述了BET蛋白抑制剂用于良性增生、动脉粥样硬化疾病、败血症、自身免疫性疾病、血管疾病、病毒感染、神经退行性疾病、炎症性疾病、动脉粥样硬化疾病和控制男性生育能力。
• Novel substituted 2,3-benzodiazepine derivatives
  申请人：——

  公开号：US20040152693A1

  公开（公告）日：2004-08-05

  The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.

  这项发明涉及新的2,3-苯二氮杂环衍生物的公式(I)，其异构体和酸盐，以及含有它们的药物组合物，以及适用于治疗与肌肉痉挛、癫痫、急性和慢性神经退行性疾病相关症状的药物组合物和使用方法，以及预防、治疗或缓解急性和慢性炎症性疾病症状的方法。
• BICYCLO 2,3-BENZODIAZEPINES AND SPIROCYCLICALLY SUBSTITUTED 2,3-BENZODIAZEPINES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160129011A1

  公开（公告）日：2016-05-12

  BET-protein-inhibitory, in particular BRD4-inhibitory bicyclo- and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), pharmaceutical compositions comprising the compounds according to the invention, and the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for tumour disorders, are described. Furthermore, the use of BET protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control is described.

  BET蛋白抑制剂，特别是BRD4抑制剂，具有一般式(I)的双环和螺环替代的2,3-苯二氮䓬类化合物，以及包含该发明化合物的药物组合物，以及其用于治疗过度增殖性疾病，特别是肿瘤性疾病的预防和治疗方法被描述。此外，描述了BET蛋白抑制剂在良性增生、动脉粥样硬化疾病、败血症、自身免疫疾病、血管疾病、病毒感染、神经退行性疾病、炎症性疾病、动脉粥样硬化疾病和男性生育控制中的用途。
• Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
  申请人：Csuzdi Emese

  公开号：US20080269202A1

  公开（公告）日：2008-10-30

  Disclosed are novel 2,3-benzodiazepine derivatives and methods of making the same.

  本发明涉及新颖的2,3-苯并二氮平衍生物及其制备方法。
• 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP0726256A1

  公开（公告）日：1996-08-14

  2,3-Benzodiazepine derivatives of general formula wherein Rrepresents hydrogen or C1-4-alkanoyl, R1stands for phenyl, optionally carrying 1 to 3 identical or different substituent(s) selected from the group consisting of halogen, nitro, amino, C1-4-alkylamino,(C1-4-alkyl)-amino, C1-4-alkanoylamino, C1-4-alkyl, C1-4-alkoxy, methylenedioxy and hydroxy; or naphthyl, optionally carrying a substituent selected from the group consisting of hydroxy, C1-4-alkyl and C1-4-alkoxy; R2stands for hydrogen or C1-4-alkyl; R3 and R4independently represent C1-4-alkyl or R3 and R4together form methylene, as well as acid addition salts and stereoisomers and mixtures thereof, and their use for preparing medicaments, particularly for the treatment of central nervous system disorders.

  通式为 2,3-苯并二氮杂卓衍生物 其中 R 代表氢或 C1-4- 烷酰基、 R1代表苯基，可选择带有 1 至 3 个相同或不同的取代基，这些取代基可从卤素、硝基、氨基、C1-4-烷基氨基、（C1-4-烷基）-氨基、C1-4-烷酰氨基、C1-4-烷基、C1-4-烷氧基、亚甲基二氧基和羟基组成的组中选出；或代表萘基，可选择带有一个从羟基、C1-4-烷基和 C1-4-烷氧基组成的组中选出的取代基； R2 代表氢或 C1-4 烷基； R3 和 R4 各自代表 C1-4-烷基，或 R3 和 R4 共同形成亚甲基、 以及酸加成盐和立体异构体及其混合物，以及它们在制备药物，特别是治疗中枢神经系统疾病方面的用途。