3,5-diamino-N-[N'-[[1-(3-aminopropanoyl)-4-(2-phenylethyl)piperidin-4-yl]methyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide | 1432293-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-diamino-N-[N'-[[1-(3-aminopropanoyl)-4-(2-phenylethyl)piperidin-4-yl]methyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide
• CAS: 1432293-27-0
• 化学式: C₂₃H₃₂ClN₉O₂
• 分子量: 502.019
• InChiKey: BQWZQUOMTCOMIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  192
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180194747A1

  公开（公告）日：2018-07-12

  The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.