6-(4-(2-ethoxyethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid | 1395998-07-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(4-(2-ethoxyethoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid
• 英文别名: 6-[4-(2-Ethoxyethoxy)-2,6-difluorophenyl]-5-fluoropyridine-2-carboxylic acid
• CAS: 1395998-07-8
• 化学式: C₁₆H₁₄F₃NO₄
• 分子量: 341.287
• InChiKey: ASNNLZNUXQLZPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• NOVEL KINASE INHIBITORS
  申请人：Burger Matthew

  公开号：US20120225062A1

  公开（公告）日：2012-09-06

  The present invention provides compounds of Formula I: and related compounds as further described herein, and pharmaceutical compositions comprising these compounds. The invention further provides methods to use these compounds and compositions for treating disorders associated with undesired levels of Pim kinase activity, including cancers and autoimmune disorders.

  本发明提供了如下式的化合物： 以及本文进一步描述的相关化合物，以及包含这些化合物的药物组合物。该发明还提供了使用这些化合物和组合物治疗与Pim激酶活性不良水平相关的疾病的方法，包括癌症和自身免疫性疾病。
• MUCOADHESIVE POLYMERS HAVING VITAMIN B PARTIAL STRUCTURES
  申请人：Leierer Johannes

  公开号：US20120225024A1

  公开（公告）日：2012-09-06

  Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partialstructures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.

  由于与黏液糖蛋白形成二硫键，聚合物化合物的粘附性能可以通过将巯基亚结构共价附加到它们上来显着改善。通过将这些聚合物上的游离巯基转化为巯基烟酰胺或巯基吡哆醇中的二硫化物，这些巯基变得更具反应性，从而显着改善了粘附性能。此外，具有巯基烟酰胺或巯基吡哆醇的二硫化物部分结构的聚合物不需要受到氧化的保护。此外，它们表现出相对较高的渗透增强性能。
• Mucoadhesive polymers having vitamin B partial structures
  申请人：THIOMATRIX FORSCHUNGS-UND BERATUNGS-GMBH

  公开号：US10639377B2

  公开（公告）日：2020-05-05

  Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.

  由于粘液糖蛋白会形成二硫桥，通过共价连接硫醇基结构，可显著改善聚合物的粘附性。通过将此类聚合物上的游离硫醇基团与巯基烟酰胺或巯基吡啶进行二硫转化，这些硫醇基团的活性会相对提高，从而显著改善粘附性。此外，具有巯基烟酰胺或巯基吡哆醇二硫化物部分结构的聚合物无需进行氧化保护。此外，它们还具有更高的渗透增强性能。
• MUCOADHESIVE SOLID OR SEMISOLID OCULAR DELIVERY SYSTEMS BASED ON PREACTIVATED THIOMERS
  申请人：Bioadhésive Ophthalmics

  公开号：EP4099979A1

  公开（公告）日：2022-12-14
• US8980238B2
  申请人：——

  公开号：US8980238B2

  公开（公告）日：2015-03-17