Phenylbrenztraubensaeure-phenylester | 60727-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenylbrenztraubensaeure-phenylester
• 英文别名: Phenyl 2-oxo-3-phenylpropanoate
• CAS: 60727-94-8
• 化学式: C₁₅H₁₂O₃
• 分子量: 240.258
• InChiKey: OUHUHUXZNNECRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 1-Sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0021678A1

  公开（公告）日：1981-01-07

  The invention relates to novel 1-sulpho-2-oxoazetidine derivatives, which are shown by the formula: wherein R, is amino, acylated amino or protected amino, and X is hydrogen or methoxy, and methods for producing them. The derivatives are of value as medicines in the treatment of bacterial infections or intermediates thereof.

  本发明涉及新型 1-磺酸基-2-氧代氮杂环丁烷衍生物，其结构如式所示： 其中R，是氨基，酰化氨基或保护氨基，X是氢或甲氧基，以及生产它们的方法。这些衍生物可作为治疗细菌感染的药物或其中间体。
• 3-Methoxy-2-oxoazetidine derivatives and their production
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0021676A1

  公开（公告）日：1981-01-07

  The invention relates to novel 3-methoxy-2-oxoazetidine derivatives, which are shown by the following formula: wherein R is amino, acylated amino or protected amino, and to methods for their production. These derivatives are of value as intermediates for the synthesis of useful compounds represented by the formula: wherein R, has the same meaning as defined above, as drugs in the treatment of bacterial infections.

  本发明涉及新型 3-甲氧基-2-氧代氮杂环丁烷衍生物，如下式所示： 其中R为氨基、酰化氨基或保护氨基，并涉及其生产方法。这些衍生物可作为合成下式所示有用化合物的中间体： 其中 R 的含义与上述定义相同，可作为治疗细菌感染的药物。
• Beta-lactamase inhibitory composition
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0050965A1

  公开（公告）日：1982-05-05

  Compounds having one or two substituents at the 3- position, represented by the general formula wherein R, is an optionally acylated or protected amino group and X is hydrogen atom or methoxy group, or a pharmaceutically acceptable salt thereof; when used either alone or in combination with a β-lactam antibiotic, show excellent β-lactamase inhibitory activity and can be used as drugs for use in humans and domestic animals.

  在 3-位上有一个或两个取代基的化合物，由通式表示，其中 R 是可选的酰化或保护氨基，X 是氢原子或甲氧基，或其药学上可接受的盐；当单独使用或与β-内酰胺类抗生素结合使用时，可显示出优异的β-内酰胺酶抑制活性，可用作人类和家畜的药物。
• Method of preparing 1-sulfo-2-oxoazetidine derivatives and intermediates therefor
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0053387A1

  公开（公告）日：1982-06-09

  1-Sulfo-2-oxoazetidine derivatives represented by the formula (I) wherein R, stands for an amino group which may optionally be acylated or protected, and X stands for hydrogen or methoxy, is produced by subjected a 1-t-butyl or isopropylsilyl derivative of a compound represented by the formula (II) wherein R2 stands for an amino group which is acylated or protected, and X is of the same meaning as defined above, to sulfonation, followed by, when R2 is a protected amino group, removing the protective group, if necessary. The compounds represented by the formula (I) have an excellent antibacterial and β-lactamase-inhibitory activity, thus being useful as drugs for humans and domestic animals.

  由式（I）表示的 1-磺基-2-氧代氮杂环丁烷衍生物 将式（II）所代表化合物的 1-叔丁基或异丙基硅烷衍生物，其中 R2 代表可选择酰化或保护的氨基，X 代表氢或甲氧基，进行硫化而制得。 其中 R2 代表酰化或受保护的氨基，X 的含义与上述定义相同。 式 (I) 所代表的化合物具有优异的抗菌和抑制 β-内酰胺酶活性，因此可作为人类和家畜的药物。
• 1-Sulfo-2-oxoazetidine derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0053816A1

  公开（公告）日：1982-06-16

  A 1-sulfo-2-oxoazetidine derivative of formula wherein R is a residue derived from an organic compound by removal of one hydrogen atom attached to a carbon atom thereof; R' is an amino group which may optionally be , acylated or protected; X is hydrogen or methoxy, and methods of producing said compound (I) which may be written as follows or wherein the symbols have the same meanings as respectively defined above. The compound (I) has improved antimicrobial and β-lactamase-inhibitory activities and is of value as drugs for human beings and domesticated animals.

  一种 1-磺基-2-氧代氮杂环丁烷衍生物，其式中，R 是有机化合物的残基，通过去除连接到其碳原子上的一个氢原子而得到；R'是氨基，可任选被酰化或保护；X 是氢或甲氧基，以及生产所述化合物 (I) 的方法，其可如下写法或其中的符号分别具有与上述定义相同的含义。 该化合物 (I) 具有更好的抗菌活性和β-内酰胺酶抑制活性，具有作为人类和驯养动物药物的价值。