2-(3',4'-dimethoxybenzoylmethyl)benzoic acid | 33863-57-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(3',4'-dimethoxybenzoylmethyl)benzoic acid
• 英文别名: 3',4'-dimethoxy-α'-oxo-bibenzyl-2-carboxylic acid；3',4'-Dimethoxy-α'-oxo-bibenzyl-2-carbonsaeure；2-<3,4-Dimethoxy-phenacyl>-benzoesaeure；2-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]benzoic acid
• CAS: 33863-57-9
• 化学式: C₁₇H₁₆O₅
• 分子量: 300.311
• InChiKey: BIVIPLJTXAOXML-UHFFFAOYSA-N

物化性质

• 熔点：
  198 °C
• 沸点：
  490.2±35.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(3',4'-dimethoxybenzoylmethyl)benzoic acid 在 乙酸酐 作用下， 反应 1.0h， 生成 3-(3',4'-dimethoxyphenyl)isocoumarin
  参考文献：
  名称：

  Ahmad, Hafiz B.; Rama, Nasim H.; Hussain, Mazhar, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 3, p. 611 - 615

  摘要：

  DOI：
• 作为产物：
  描述：

  邻羧基苯乙酸 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 2-(3',4'-dimethoxybenzoylmethyl)benzoic acid
  参考文献：
  名称：

  8-Desoxythunberginol A 和 (±)-8-Desoxy-3,4-Dihydrothunberginol A 的合成

  摘要：

  已经描述了从长叶Homalium longifolium中分离的标题异香豆素的两步合成及其转化为相应的3,4-二氢异香豆素。3,4-二甲氧基苯甲酰氯与高邻苯二甲酸缩合得到 3-(3',4'-二甲氧基苯基)异香豆素，将其去甲基化得到 8-脱氧紫杉醇 A，而其顺序皂化、还原和去甲基化得到 (±)-8 -desoxy-3,4-dihydrothunberginol A. 在体外检测合成的化合物的抗菌活性。

  DOI：

  10.1002/jccs.200300046

文献信息

• The Preparation of 2-(2-Oxo-2-Phenylethyl) Benzoic Acids from Dilithiated<i>Ortho-</i>Toluic Acid.
  作者：Tina S. Guion、Madlene U. Koller、Rene J. Lachicotte、Robin N. Rutledge、Karen C. Hildebran、Phuong H. Le、Charles F. Beam

  DOI：10.1080/00397919608002615

  日期：1996.5

  Abstract ortho-Toluic acid was dimetalated with excess lithium diisopropylamide, and the resulting intermediate was condensed with a variety of aromatic esters to afford new substituted 2-(2-oxo-2-phenylethyl)benzoic acids (ortho-phenacylbenzoic acids).

  摘要 用过量的二异丙基氨基锂对邻甲苯甲酸进行二金属化，所得中间体与多种芳香酯缩合得到新的取代的 2-(2-氧代-2-苯基乙基)苯甲酸（邻苯甲酰基苯甲酸）。
• Legrand,L.; Lozach,N., Bulletin de la Societe Chimique de France, 1964, p. 1787 - 1793
  作者：Legrand,L.、Lozach,N.

  DOI：——

  日期：——
• Translaryngeal open ventilation to treat acute respiratory failure in acute exacerbation of chronic obstructive pulmonary disease. A preliminary report
  作者：Yoanna Skrobik、Cesare Gregoretti

  DOI：10.1007/bf03020385

  日期：2001.12

  Purpose: To describe a minimally invasive alternative to conventional mechanical ventilation, using a small size uncuffed nasotracheal tube (translaryngeal open ventilation) paired with pressure control ventilation, in acute respiratory failure complicating chronic obstructive pulmonary disease (COPD).Clinical features: Two cooperative COPD patients, who failed noninvasive mechanical ventilation, were intubated nasotracheally, Mechanical ventilation was initiated in pressure control mode via an uncuffed 6 mm tube.Results: Respiratory rate improved after I hour (from 44 to 28 breaths.min(-1) in case I and from 32 to 25 breaths.min(-1) in case 2); PaCO2 decreased (from 120 to 62 mmHg in case I and from 69 to 51 mmHg in case 2); with pressure control mode levels of 45 cm H2O and 55 cm H2O respectively, PaO2 increased from 40 mmHg (with FlO(2) 0.3) to 55 mmHg (with FlO(2) 0.3) in the first patient and from 55 mmHg (with FlO(2) 0.4) to 60 mmHg (with FlO(2) 0.4) in the second patient; pH improved from 7.18 to 7.31 in case I and from 7.22 to 7.39 in case 2. Patients were able to trigger the ventilator, speak, swallow and to clear secretions spontaneously. Both patients were ventilated for three days in this manner without any adverse effects. Both survived and were discharged home after 20 and 18 days in hospital respectively.Conclusion: This very preliminary report suggests that, in carefully selected patients who fail mask ventilation, mechanical support with translaryngeal open ventilation can improve gas exchange, breathing pattern and tachypnea, without hindering glottic function.