1-(3R,4R)-3,4-bis(((9Z,12Z)-octadec-9,12-dienyloxy)pyrrolidine-1-yl)-3-methoxypropan-2-ol | 1346224-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3R,4R)-3,4-bis(((9Z,12Z)-octadec-9,12-dienyloxy)pyrrolidine-1-yl)-3-methoxypropan-2-ol
• 英文别名: 1-[(3R,4R)-3,4-bis[(9Z,12Z)-octadeca-9,12-dienoxy]pyrrolidin-1-yl]-3-methoxypropan-2-ol
• CAS: 1346224-98-3
• 化学式: C₄₄H₈₁NO₄
• 分子量: 688.131
• InChiKey: FHYUPAUKKVKGCK-QEQZCXPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.5
• 重原子数：
  49
• 可旋转键数：
  36
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• LIPID NANO PARTICLES COMPRISING COMBINATION OF CATIONIC LIPID
  申请人：KYOWA HAKKO KIRIN CO., LTD.

  公开号：US20140045913A1

  公开（公告）日：2014-02-13

  The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 3 is absent or is alkyl, etc, X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y 1 is absent or anion, L 1 is a single bond, etc, R 3 is alkyl, etc), and a cationic lipid represented by formula (II) (wherein: R 4 and R 5 are, the same or different, alkenyl, etc, and X 4 and X 5 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X 6 is absent or is alkyl, etc, Y 2 is absent or anion, a and b are, the same or different, 0 to 3, and L 4 is a single bond, etc, R 6 is alkyl, etc, L 2 and L 3 are —O—, —CO—O— or —O—CO—), and the like.

  本发明提供了一种脂质纳米粒子，可以使核酸轻松地进入细胞，包括由式(I)表示的阳离子脂质（其中：R1和R2是相同或不同的烯基等，X3不存在或是烷基等，X1和X2是氢原子，或结合在一起形成单键或亚烷基，Y1不存在或是阴离子，L1是单键等，R3是烷基等），以及由式(II)表示的阳离子脂质（其中：R4和R5是相同或不同的烯基等，X4和X5是氢原子，或结合在一起形成单键或亚烷基，X6不存在或是烷基等，Y2不存在或是阴离子，a和b是相同或不同的0到3，L4是单键等，R6是烷基等，L2和L3是—O—，—CO—O—或—O—CO—）等。
• CATIONIC LIPID
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US20130280305A1

  公开（公告）日：2013-10-24

  The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X 3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L 3 is a single bond, etc, R 3 is alkyl, etc, L 1 and L 2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.

  本发明提供了一种阳离子脂质，其允许核酸轻松进入细胞，其表示为式(I)（其中：R1和R2为相同或不同的烯基等，X1和X2为氢原子，或结合在一起形成单键或烷基，X3不存在或为烷基等，Y不存在或为阴离子，a和b为相同或不同的0到3，L3为单键等，R3为烷基等，L1和L2为—O—，—CO—O—或—O—CO—），一种包含该阳离子脂质和核酸的组合物，以及一种通过使用包含该阳离子脂质和核酸的组合物将核酸引入细胞的方法，等等。
• US9845306B2
  申请人：——

  公开号：US9845306B2

  公开（公告）日：2017-12-19
• US9920028B2
  申请人：——

  公开号：US9920028B2

  公开（公告）日：2018-03-20