2,6-dichloroaniline hydrochloride | 33663-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dichloroaniline hydrochloride
• 英文别名: 2,6-Cl2C6H3NH3Cl；2,6-dichloroaniline;hydrochloride
• CAS: 33663-43-3
• 化学式: C₆H₆Cl₂N*Cl
• 分子量: 198.479
• InChiKey: HHTCWTPRRICITN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-dichloroaniline hydrochloride 在 氨 、 碳酸氢钠 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 12.5h， 生成 2,6-二氯苯基硫脲
  参考文献：
  名称：

  Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors

  摘要：

  The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino- 1,3-thiazolyl]-thiophene-2-carboxamidine is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00102-0
• 作为产物：
  描述：

  Re(N-2,6-C6H3Me2)3(CH2t-Bu) 在 盐酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 以78%的产率得到Re(N-2,6-C6H3Cl2)2(CH2t-Bu)Cl2
  参考文献：
  名称：

  VII（VII）的双（三）和三（芳基）配合物的制备，包括双（新亚芳基）新亚戊二烯配合物，可作为烯烃复分解催化剂

  摘要：

  ReO 3（OSiMe 3）和3当量之间的反应。ARNCO比（Ar = 2,6--C 6 H ^ 3我镨2）得到的（ARN）的混合物3 ReORe（O）（NAR）2（1）中，Re（O）（NAR）3（OSiMe 3）（2a），以及被提议为Re（O）（NAr）2（OSiMe 3）（3）。可以改变条件以便以令人满意的产率产生1或2a，但是还没有以纯形式制备3。ReO 3（OSiMe3）和3当量 Ar'NCO比（Ar'= 2,6-C 6 H ^ 3我2）产率（Ar'N）3 ReORe（NAR'）3（4）和R e（NAR'）3（OSiMe 3） （2b），而在ReO 3（OSiMe 3）和3 equiv之间。Ar″ NCO（Ar″ ＝ 2，6-C 6 H 3 Cl 2）的化合物仅产生Re（NAr″）3（OSiMe 3）（2c）。Re（NR）3（CH 2 tBu）（R = Ar，Ar'，Ar''）已直接制备。Re（NR）2

  DOI：

  10.1016/s0277-5387(00)80695-6

文献信息

• Antihypertensive (2-aminoethyl)thiourea derivatives. 1
  作者：Jefferson W. Tilley、Paul Levitan、Richard W. Kierstead、Michael Cohen

  DOI：10.1021/jm00186a019

  日期：1980.12

  Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas. From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog. In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.
• 2-Amino-4<i>H</i>-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease
  作者：Sheryl J. Hays、Bradley W. Caprathe、John L. Gilmore、Nilam Amin、Mark R. Emmerling、Walter Michael、Ravi Nadimpalli、Rathna Nath、Kadee J. Raser、Daniel Stafford、Desiree Watson、Kevin Wang、Juan C. Jaen

  DOI：10.1021/jm970394d

  日期：1998.3.1

  A series of 2-amino-4H-3,1-benzoxazin-4-ones have been synthesized and evaluated as inhibitors of the complement enzyme C1r. C1r is a serine protease at the beginning of the complement cascade, and complement activation by beta-amyloid may represent a major contributing pathway to the neuropathology of Alzheimer's disease. Compounds such as 7-chloro-2-[(2-iodophenyl)amino]benz[d][1,3]oxazin-4-one (32) and 7-methyl-2-[(2-iodophenyl)amino]benz[d] 4-one (37) show improved potency compared to the reference compound FUT-175. Many of these active compounds also possess increased selectivity for C1r compared to trypsin and enhanced hydrolytic stability relative to 2-(2-iodophenyl)-4H-3,1-benzoxazin-4-one (1).
• A novel aromatic alkylation of anilines with cyclic and acyclic ketones under hydrothermal conditions
  作者：Barun K. Mehta、Koji Kumamoto、Kazumichi Yanagisawa、Hiyoshizo Kotsuki

  DOI：10.1016/j.tetlet.2005.07.165

  日期：2005.10

  A novel aromatic ring-alkylation was achieved by condensation between aniline(.)HCI salts and cyclic or acyclic ketones under hydrothermal conditions. (c) 2005 Elsevier Ltd. All rights reserved.
• Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors
  作者：Kenneth J. Wilson、Carl R. Illig、Nalin Subasinghe、James B. Hoffman、M. Jonathan Rudolph、Richard Soll、Christopher J. Molloy、Roger Bone、David Green、Troy Randall、Marie Zhang、Frank A. Lewandowski、Zhao Zhou、Celia Sharp、Diane Maguire、Bruce Grasberger、Renee L. DesJarlais、John Spurlino

  DOI：10.1016/s0960-894x(01)00102-0

  日期：2001.4

  The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino- 1,3-thiazolyl]-thiophene-2-carboxamidine is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Preparation of bis and tris(arylimido) complexes of rhenium(VII), including bis(arylimido) neopentylidene complexes, candidates as olefin metathesis catalysts
  作者：Andrew D. Horton、Richard R. Schrock

  DOI：10.1016/s0277-5387(00)80695-6

  日期：1988.1

  Ar″NCO (Ar″ = 2,6-C6H3Cl2) yield only Re(NAr″)3(OSiMe3) (2c). Complexes of the type Re(NR)3(CH2tBu) (R = Ar, Ar′, Ar″) have been prepared straightforwardly. Complexes of the type Re(NR)2Cl3(py) (6) can be prepared by treating tris(imido) complexes 2 with 3 equiv. of pyHCl. These can be alkylated to give mononeopentyl bis(imido) derivatives, Re(NR)2(CH2tBu)Cl2 (8), in high yield. Dehydrohalogenation of

  ReO 3（OSiMe 3）和3当量之间的反应。ARNCO比（Ar = 2,6--C 6 H ^ 3我镨2）得到的（ARN）的混合物3 ReORe（O）（NAR）2（1）中，Re（O）（NAR）3（OSiMe 3）（2a），以及被提议为Re（O）（NAr）2（OSiMe 3）（3）。可以改变条件以便以令人满意的产率产生1或2a，但是还没有以纯形式制备3。ReO 3（OSiMe3）和3当量 Ar'NCO比（Ar'= 2,6-C 6 H ^ 3我2）产率（Ar'N）3 ReORe（NAR'）3（4）和R e（NAR'）3（OSiMe 3） （2b），而在ReO 3（OSiMe 3）和3 equiv之间。Ar″ NCO（Ar″ ＝ 2，6-C 6 H 3 Cl 2）的化合物仅产生Re（NAr″）3（OSiMe 3）（2c）。Re（NR）3（CH 2 tBu）（R = Ar，Ar'，Ar''）已直接制备。Re（NR）2