N'-(3,5-dichloro-2-hydroxybenzylidene)-2-hydroxy-3-methylbenzohydrazide | 1349180-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(3,5-dichloro-2-hydroxybenzylidene)-2-hydroxy-3-methylbenzohydrazide
• 英文别名: N-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylideneamino]-2-hydroxy-3-methylbenzamide
• CAS: 1349180-96-6
• 化学式: C₁₅H₁₂Cl₂N₂O₃
• 分子量: 339.178
• InChiKey: UCPUSQHZVYPQPP-CNHKJKLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  81.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-羟基-3-甲基亚苯基肼 、 3,5-二氯水杨醛 以 甲醇 为溶剂， 反应 1.0h， 以96%的产率得到N'-(3,5-dichloro-2-hydroxybenzylidene)-2-hydroxy-3-methylbenzohydrazide
  参考文献：
  名称：

  Synthesis, Crystal Structures, and Antifungal Activities of N’-3,5-Dichloro-2-hydroxybenzylidene)-2-hydroxy-3-methylbenzohydrazide and its Oxovanadium(V) Complex [N’-(3,5-Dichloro-2-oxidobenzylidene-κO)-2-hydroxy-3-methylbenzohydrazidato-κ ² N’,O](methanol-κO)(methanolato-κO)oxidovanadium(V)

  摘要：

  A new hydrazine ligand, N'-3,5-dichloro-2-hydroxybenzylidene)-2-hydroxy-3-methylbenzohydrazide, and its oxovanadium(V) complex, [N'-(3,5-dichloro-2-oxidobenzylidene-kappa O)2-hydroxy-3-methylbenzohydrazidato-kappa N-2',O](methanol-kappa O)(methanolato-kappa O)oxidovanadium(V), were prepared and were structurally characterized by elemental analysis, infrared (IR) spectra, and single-crystal x-ray diffraction. The hydrazine ligand coordinates to the V atom through the phenolic O, imino N, and ethanolic O atoms. The V atom in the complex is in an octahedral coordination, with the three donor atoms of the hydrazine ligand and one methanolato O atom defining the equatorial plane, and with onemethanol O atom and one oxo O atom occupying the axial positions. The displacement of the V atom from the equatorial plane toward the axial oxo O atom is 0.308(2) angstrom. The hydrazine ligand and the complex showed moderate to strong antifungal activities against the fungi Aspergillus flavus, Fusarium, and Candida albicans.

  DOI：

  10.1080/15533174.2011.591353

文献信息

• FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
  申请人：Young David H.

  公开号：US20120107416A1

  公开（公告）日：2012-05-03

  The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.

  本发明涉及利用肼酮化合物和铜控制真菌生长。
• SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
  申请人：Young David H.

  公开号：US20120010075A1

  公开（公告）日：2012-01-12

  The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.

  本发明涉及使用含有肼化合物和铜的混合物来控制真菌生长。
• US8461078B2
  申请人：——

  公开号：US8461078B2

  公开（公告）日：2013-06-11