2-(5-fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate | 1259929-75-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(5-fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate
• CAS: 1259929-75-3
• 化学式: C₁₄H₁₄FNO₃S
• 分子量: 295.334
• InChiKey: BPHIYJUODCJVDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide 、 2-(5-fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate 生成 7-(4-(2-(5-fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide
  参考文献：
  名称：

  2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774

  摘要：

  本发明涉及式（I）的化合物，其中R1为杂环芳基或杂环烷基，可选地取代；R2为C1-4烷基、杂环基、C1-4烷基芳基、C1-4烷基杂环芳基、碳环基、C1-4烷基杂环基、杂环基-杂环芳基、芳基-杂环基、碳环基-杂环芳基、杂环基-芳基，可选地取代；R3为氢或C1-4烷基，或R2和R3可以与氮原子一起形成含有4、5或6个环形成原子的饱和环系统，可选地取代；R4为氢、卤素、甲基或甲氧基；含有所述化合物的制药组合物以及所述化合物在治疗中的使用，例如治疗认知障碍。本发明还涉及在其制备中有用的新中间体。

  公开号：

  US20100331341A1

文献信息

• 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
  申请人：Andersson Johan

  公开号：US08367676B2

  公开（公告）日：2013-02-05

  The present invention relates to compounds of formula (I), wherein R1 is heteroaryl or heterocyclyl, optionally substituted; R2 is C1-4alkyl, heterocyclyl, C1-4alkylaryl, C1-4alkylheteroaryl, carbocyclyl, C1-4alkylheterocyclyl, heterocyclyl-heteroaryl, aryl-heterocyclyl, carbocyclyl-heteroaryl, heterocyclyl-aryl, optionally substituted; R3 is hydrogen or C1-4alkyl, or R2 and R3 may together with the nitrogen atom, form a saturated ring system containing 4, 5 or 6 ring forming atoms, and optionally substituted; R4 is hydrogen, halogen, methyl or methoxy; to pharmaceutical composition containing said compounds and to the use of said compounds in therapy, for instance in treating cognitive disorders. The present invention further relates to new intermediates useful in the preparation thereof.

  本发明涉及式（I）的化合物，其中R1为杂环芳基或杂环烷基，可选地取代；R2为C1-4烷基，杂环基，C1-4烷基芳基，C1-4烷基杂环芳基，碳环基，C1-4烷基杂环基，杂环基-杂环芳基，芳基-杂环基，碳环基-杂环芳基，杂环基-芳基，可选地取代；R3为氢或C1-4烷基，或R2和R3可以与氮原子一起形成含有4、5或6个环形成原子的饱和环系统，可选地取代；R4为氢、卤素、甲基或甲氧基；含有上述化合物的制药组合物以及上述化合物在治疗中的用途，例如治疗认知障碍。本发明还涉及在制备中有用的新中间体。
• 2-carboxamide-7-piperazinyl-benzofuran derivatives
  申请人：AstraZeneca AB

  公开号：US08859534B2

  公开（公告）日：2014-10-14

  The present invention relates to compounds of formula (I), wherein R1 is heteroaryl or heterocyclyl, optionally substituted; R2 is C1-4alkyl, heterocyclyl, C1-4alkylaryl, C1-4alkylheteroaryl, carbocyclyl, C1-4alkylheterocyclyl, heterocyclyl-heteroaryl, aryl-heterocyclyl, carbocyclyl-heteroaryl, heterocyclyl-aryl, optionally substituted; R3 is hydrogen or C1-4alkyl, or R2 and R3 may together with the nitrogen atom, form a saturated ring system containing 4, 5 or 6 ring forming atoms, and optionally substituted; R4 is hydrogen, halogen, methyl or methoxy; to pharmaceutical composition containing said compounds and to the use of said compounds in therapy, for instance in treating cognitive disorders. The present invention further relates to new intermediates useful in the preparation thereof.

  本发明涉及公式（I）的化合物，其中R1是杂环芳基或杂环烷基，可选择性取代；R2是C1-4烷基，杂环基，C1-4烷基芳基，C1-4烷基杂环芳基，碳环基，C1-4烷基杂环基，杂环基-杂环芳基，芳基-杂环基，碳环基-杂环芳基，杂环基-芳基，可选择性取代；R3是氢或C1-4烷基，或R2和R3可以与氮原子一起形成含有4、5或6个环形成原子的饱和环系统，可选择性取代；R4是氢、卤素、甲基或甲氧基；以及含有该化合物的制药组合物以及该化合物在治疗中的使用，例如用于治疗认知障碍。本发明还涉及在其制备中有用的新中间体。
• 2-Carboxamide-7-Piperazinyl-Benzofuran Derivatives
  申请人：ASTRAZENECA AB

  公开号：US20130296296A1

  公开（公告）日：2013-11-07

  The present invention relates to compounds of formula (I), wherein R 1 is heteroaryl or heterocyclyl, optionally substituted; R 2 is C 1-4 alkyl, heterocyclyl, C 1-4 alkylaryl, C 1-4 alkylheteroaryl, carbocyclyl, C 1-4 alkylheterocyclyl, heterocyclyl-heteroaryl, aryl-heterocyclyl, carbocyclyl-heteroaryl, heterocyclyl-aryl, optionally substituted; R 3 is hydrogen or C 1-4 alkyl, or R 2 and R 3 may together with the nitrogen atom, form a saturated ring system containing 4, 5 or 6 ring forming atoms, and optionally substituted; R 4 is hydrogen, halogen, methyl or methoxy; to pharmaceutical composition containing said compounds and to the use of said compounds in therapy, for instance in treating cognitive disorders. The present invention further relates to new intermediates useful in the preparation thereof.

  本发明涉及式（I）的化合物，其中R1是杂环芳基或杂环基，可选地被取代；R2是C1-4烷基，杂环基，C1-4烷基芳基，C1-4烷基杂环芳基，碳环基，C1-4烷基杂环基，杂环基-杂环芳基，芳基-杂环基，碳环基-杂环芳基，杂环基-芳基，可选地被取代；R3是氢或C1-4烷基，或R2和R3可以与氮原子一起形成4、5或6个环形成原子的饱和环系统，可选地被取代；R4是氢、卤素、甲基或甲氧基；以及含有所述化合物的制药组合物和所述化合物在治疗中的用途，例如用于治疗认知障碍。本发明还涉及在其制备中有用的新中间体。
• 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP2448934B1

  公开（公告）日：2014-05-21
• US8367676B2
  申请人：——

  公开号：US8367676B2

  公开（公告）日：2013-02-05