(R)-4-(3-(2-allyloxyethyl)-2-benzyloxy-1-naphthyl)-3-benzyloxy-2-naphthaleneacetaldehyde | 350490-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-4-(3-(2-allyloxyethyl)-2-benzyloxy-1-naphthyl)-3-benzyloxy-2-naphthaleneacetaldehyde
• CAS: 350490-38-9
• 化学式: C₄₁H₃₆O₄
• 分子量: 592.734
• InChiKey: IGXWGGXDZYMGQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  45.0
• 可旋转键数：
  14.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-4-(3-(2-allyloxyethyl)-2-benzyloxy-1-naphthyl)-3-benzyloxy-2-naphthaleneacetaldehyde 在 三乙基硅烷 、 四(三苯基膦)钯 、 三氟甲磺酸三甲基硅酯 、 三正丁基氢锡 、 lithium 、 氯化铵 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 氨 为溶剂， 反应 2.22h， 生成 (R,R)-3,3''-oxydiethylene-di-(2,2'-dihydroxy-3'-(2-hydroxyethyl)-1,1'-binaphthyl)
  参考文献：
  名称：

  Direct catalytic asymmetric aldol reactions promoted by novel heterobimetallic catalysts possessing strong Brønsted base: a new strategy for the development of Lewis acid–Brønsted base bifunctional catalysts

  摘要：

  Novel heterobimetallic catalysts possessing lithium alkoxide as Bronsted base have been developed. The catalysts were found to be effective in the direct asymmetric aldol reaction of less acidic dialkyl ketones as well as aromatic ketones, affording the aldol products in moderate yield and ee. Attempts at diastereo- and enantioselective direct catalytic aldol reaction of ethyl ketone using small molecule catalysts are reported for the first time. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(01)00070-9
• 作为产物：
  描述：

  (R)-3,3'-bis(2-hydroxyethyl)-2,2'-bis(methoxymethyloxy)-1,1'-binaphthyl 在 potassium fluoride on basic alumina 、 戴斯-马丁氧化剂 、 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 32.0h， 生成 (R)-4-(3-(2-allyloxyethyl)-2-benzyloxy-1-naphthyl)-3-benzyloxy-2-naphthaleneacetaldehyde
  参考文献：
  名称：

  Direct catalytic asymmetric aldol reactions promoted by novel heterobimetallic catalysts possessing strong Brønsted base: a new strategy for the development of Lewis acid–Brønsted base bifunctional catalysts

  摘要：

  Novel heterobimetallic catalysts possessing lithium alkoxide as Bronsted base have been developed. The catalysts were found to be effective in the direct asymmetric aldol reaction of less acidic dialkyl ketones as well as aromatic ketones, affording the aldol products in moderate yield and ee. Attempts at diastereo- and enantioselective direct catalytic aldol reaction of ethyl ketone using small molecule catalysts are reported for the first time. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(01)00070-9