4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-ethoxy-benzamide | 4093-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-ethoxy-benzamide
• 英文别名: 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-ethoxybenzamide
• CAS: 4093-37-2
• 化学式: C₁₅H₂₄ClN₃O₂
• 分子量: 313.827
• InChiKey: MJWPEAZCTWFVJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] METHOD FOR PREPARING 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE AS ITOPRIDE HYDROCLORIDE SALT MEDIATE<br/>[FR] PROCEDE DE PREPARATION DE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE COMME SEL ITOPRIDE-HYDROCHLORURE INTERMEDIAIRE
  申请人：IL YANG PHARM CO LTD

  公开号：WO2006011696A1

  公开（公告）日：2006-02-02

  The present invention relates to a novel method for preparing an itopride·hydrochloride mediate of the formula 1, which is useful for digestive tract activator, and more particularly, the present invention provides with a method for preparing 4-[2-(dimethylamino)ethoxy]benzylamine of the formula 1, an itopride·hydrochloride mediate, whereby being capable of manufacturing in a high yield and lowering cost through a simple purification and a selective reaction, and the method is harmless and safe to human and environment due to not generating toxic gas. And specially, a super-high pressure hydrogenation and a reduction reaction using a metal catalyst are not carried out, therefore, it is very safe method, and also special manufacturing equipments are not needed.

  本发明涉及一种制备消化道活化剂的伊托品盐酸盐中间体1的新方法，更具体地说，本发明提供了一种制备伊托品盐酸盐中间体4-[2-(二甲基氨基)乙氧基]苯甲胺1的方法，通过简单的纯化和选择性反应，能够高产率地制造，并降低成本，该方法对人体和环境无害，不会产生有毒气体。特别地，本方法不进行超高压氢化和金属催化剂还原反应，因此非常安全，也不需要特殊的制造设备。
• METHOD FOR PREPARING 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE AS ITOPRIDE HYDROCLORIDE SALT MEDIATE
  申请人：Il Yang Pharm. Co. Ltd.

  公开号：EP1771408A1

  公开（公告）日：2007-04-11
• EP1771408A4
  申请人：——

  公开号：EP1771408A4

  公开（公告）日：2007-08-29