1-allyl-3-(R)-(phenethyl(phenyl)carbamoyloxy)-1-azoniabicyclo[2.2.2]octane bromide | 439909-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-allyl-3-(R)-(phenethyl(phenyl)carbamoyloxy)-1-azoniabicyclo[2.2.2]octane bromide
• 英文别名: [(3R)-1-prop-2-enyl-1-azoniabicyclo[2.2.2]octan-3-yl] N-phenyl-N-(2-phenylethyl)carbamate;2,2,2-trifluoroacetate
• CAS: 439909-14-5
• 化学式: C₂F₃O₂*C₂₅H₃₁N₂O₂
• 分子量: 504.549
• InChiKey: JWMWRHOWJNBSQF-CBTDTNIQSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.97
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
  申请人：Prat Quinones Maria

  公开号：US20090005412A1

  公开（公告）日：2009-01-01

  Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

  公开了化学式（I）的氨基甲酸酯或其药学上可接受的盐，包括化学式（II）的季铵盐；以及它们的制备方法、包含它们的制药组合物以及它们作为M3胆碱能受体拮抗剂在治疗中的应用。
• NOVEL QUINUCLIDINE CARBAMATE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
  申请人：QUINONES Maria PRAT

  公开号：US20090054480A1

  公开（公告）日：2009-02-26

  Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

  本文披露了式(I)的氨基甲酸酯或其药学上可接受的盐，包括式(II)的季铵盐，以及它们的制备过程、包含它们的制药组合物以及它们作为M3胆碱能受体拮抗剂在治疗中的应用。