2,6-dimethyl-4-neopentylphenol | 353793-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dimethyl-4-neopentylphenol
• 英文别名: 4-(2,2-Dimethylpropyl)-2,6-dimethylphenol
• CAS: 353793-69-8
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: GIUQVIBQERNEGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-dimethyl-4-neopentylphenol 在 copper diacetate 、 乙二醇 作用下， 反应 12.0h， 以62%的产率得到1-(4-hydroxy-3,5-dimethylphenyl)-2,2-dimethylpropan-1-one
  参考文献：
  名称：

  Cu（OAc）2催化的远位苄基C（sp 3）-H氧基官能化，在无配体和无添加剂条件下，以受阻的对羟基在环境空气中作为末端氧化剂，指导C O的形成

  摘要：

  已经开发了一种受阻的对羟基定向的远程苄基C（sp 3）–H氧官能团，用于将2,6-二取代的4-甲酚，4-烷基苯酚，4-羟基苄醇和4-羟基苄基烷基醚直接转化为各种芳族羰基化合物。由乙二醇介导的无配体和无添加剂的Cu（OAc）2催化的大气氧化作用，可以使伯苄基和仲苄基官能化，形成简便，原子经济且对环境无害的C O形成。由于4-羟基苯甲醛和4-羟基苯酮的药物重要性，因此该方法对于基础研究和实际应用均具有重要价值。

  DOI：

  10.1039/c3gc41946k

文献信息

• 1,2-ALKANE POLYOL-CONTAINING COMPOSITION
  申请人：Osaka Organic Chemical Ind., Ltd.

  公开号：EP2985017A1

  公开（公告）日：2016-02-17

  Provided is a composition containing, as an alkane polyol, a C4-18 1,2-alkane polyol in which the degradation over time of the C4-18 1,2-alkane polyol, which has inferior chemical stability and degrades easily, is suppressed, the composition being suitable for use in a cosmetic, an inkjet ink, a fiber or a coating material such as a paint. A composition containing 1,2-alkane polyol that can be used in a cosmetic, an inkjet ink, a raw material for fibers or a coating material, the alkane polyol being a C4-18 1,2-alkane polyol, and the composition containing a radical scavenger.

  本发明提供了一种含有 C4-18 1,2-烷烃多元醇作为烷烃多元醇的组合物，在该组合物中，化学稳定性较差且容易降解的 C4-18 1,2-烷烃多元醇随时间推移的降解受到抑制，该组合物适用于化妆品、喷墨墨水、纤维或涂料等涂层材料。一种含有 1,2-烷烃多元醇的组合物，可用于化妆品、喷墨墨水、纤维原料或涂层材料，烷烃多元醇为 C4-18 1,2-烷烃多元醇，组合物中含有自由基清除剂。
• Intermediates for macrocyclic compounds
  申请人：OCERA THERAPEUTICS, INC.

  公开号：US10040751B2

  公开（公告）日：2018-08-07

  The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as described in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

  本发明涉及式（I）的新型大环化合物及其药学上可接受的盐、水合物或溶液： 其中 R1、R2、R3、R4、R5、R6、n1、m、p Z1、Z2 和 Z3 如说明书所述。本发明还涉及式（I）化合物，该化合物是动情素受体的拮抗剂，可用于治疗与该受体相关的疾病以及运动功能障碍。
• Polyolefin fiber having improved initial elongation and process for preparation thereof
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0320188B1

  公开（公告）日：1995-02-22
• Agricultural articles
  申请人：Bonora Michael

  公开号：US20070135537A1

  公开（公告）日：2007-06-14

  The present invention relates to agricultural articles which keep their properties during the use and degrade later on, until total disintegration and disappearance of the plastic. The invention further relates to a method for controlling the weathering resistance and the degradation of agricultural articles. The desired effect is obtained with specific combinations of degradant metal salts and stabilizers. The agricultural article of the present invention comprises an organic polymer, an organic salt of Fe, Ce, Co, Mn, Cu or Vd and one or more sterically hindered amine compounds.
• Porous Inorganic Materials Containing Polymer Additives
  申请人：Brand Jean Fabien

  公开号：US20080058459A1

  公开（公告）日：2008-03-06

  The present invention relates to SiO z flakes, especially porous SiO z flakes, wherein 0.70≦z≦2.0, especially 0.95≦z≦2.0, comprising a polymer additive in the pores, which provides enhanced (long term) efficacy. Further aspects of the invention are a process for their preparation and a polymer composition containing such SiO z flakes.