3-(4-(2-(N-isopropylsulfamoyl)phenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide | 1384860-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-(2-(N-isopropylsulfamoyl)phenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide
• 英文别名: N-methyl-3-[[4-[2-(propan-2-ylsulfamoyl)anilino]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]benzamide
• CAS: 1384860-07-4
• 化学式: C₂₃H₂₇N₇O₃S
• 分子量: 481.578
• InChiKey: OFQMYGWFTGXFND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• Liquid crystal device, method for manufacturing a liquid crystal device, and method for operating a liquid crystal device
  申请人：Electronics and Telecommunications Research Institute

  公开号：US10156760B2

  公开（公告）日：2018-12-18

  A method for manufacturing a liquid crystal device includes preparing a precursor solution comprising a monomer, a blue dye, a green dye, and a red dye dissolved in the monomer, and liquid crystal molecules; and polymerizing the monomer of the precursor solution to form a liquid crystal layer. The blue dye, the green dye, and the red dye reflect light of different wavelengths from each other. A black color is available in a single pixel when, based on total amount of the blue dye, the green dye, and the red dye, the blue dye is present in an amount ranging from about 25 wt % to about 30 wt %, the green dye is present in an amount ranging from about 40 wt % to about 50 wt %, and the red dye is present in an amount ranging from about 25 wt % to about 30 wt %.

  一种制造液晶器件的方法包括制备前驱体溶液，其中包括单体、溶解在单体中的蓝色染料、绿色染料和红色染料以及液晶分子；以及聚合前驱体溶液的单体以形成液晶层。蓝色染料、绿色染料和红色染料相互反射不同波长的光。如果根据蓝色染料、绿色染料和红色染料的总量，蓝色染料的含量在约 25 wt % 到约 30 wt % 之间，绿色染料的含量在约 40 wt % 到约 50 wt % 之间，红色染料的含量在约 25 wt % 到约 30 wt % 之间，则在单个像素中可获得黑色。
• LIQUID CRYSTAL DEVICE, METHODS FOR MANUFACTURING A LIQUID CRYSTAL DEVICE, AND METHODS FOR OPERATING A LIQUID CRYSTAL DEVICE
  申请人：Electronics and Telecommunications Research Institute

  公开号：US20180136507A1

  公开（公告）日：2018-05-17

  Provided are a liquid crystal device, a method for manufacturing a liquid crystal device, and a method for operating a liquid crystal device. According to the inventive concept, a method for manufacturing a liquid crystal device includes preparing a precursor solution including a monomer, liquid crystal molecules, a first dye, a second dye, and a third dye, and performing a polymerization process of the precursor solution to form a liquid crystal layer. The first dye, the second dye, and the third dye may reflect lights having different wavelengths from each other.
• US9428508B2
  申请人：——

  公开号：US9428508B2

  公开（公告）日：2016-08-30