2-(4-Chlorophenyl)-N-{[4-(3,4-dichlorobenzyl)-5,5-dimethylmorpholin-2-yl]methyl}acetamide | 407637-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Chlorophenyl)-N-{[4-(3,4-dichlorobenzyl)-5,5-dimethylmorpholin-2-yl]methyl}acetamide
• 英文别名: 2-(4-chlorophenyl)-N-[[4-[(3,4-dichlorophenyl)methyl]-5,5-dimethylmorpholin-2-yl]methyl]acetamide
• CAS: 407637-74-5
• 化学式: C₂₂H₂₅Cl₃N₂O₂
• 分子量: 455.812
• InChiKey: VZXHCMDYUZPSNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-[4-(3,4-Dichlorobenzyl)-5,5-dimethylmorpholin-2-yl]methanamine 、 对氯苯乙酸 在 crude mixture 、 silica gel 、 cyclohexane, ethyl acetate 、 乙醚 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.07h， 以to give the title compound as an off-white solid (0.018 g)的产率得到2-(4-Chlorophenyl)-N-{[4-(3,4-dichlorobenzyl)-5,5-dimethylmorpholin-2-yl]methyl}acetamide
  参考文献：
  名称：

  Morpholin-acetamide derivatives for the treatment of inflammatory diseases

  摘要：

  本发明涉及一种新型的吗啡啶酰胺化合物（I式），其可用于治疗炎症性疾病。化合物（I式）中，R1、R2、R3、R4、R5、X、a、b和Z的定义见说明书，本发明还涉及制备这些化合物的方法、含有它们的制剂以及它们在治疗炎症性疾病中的应用。

  公开号：

  US07101882B2

文献信息

• Process for the preparation of morpholine derivatives and intermediates therefore
  申请人：Hayes Alistair Martin

  公开号：US20050222147A1

  公开（公告）日：2005-10-06

  Processes for the preparation of a compound of formula (IIIA) or a salt thereof are disclosed.

  本发明揭示了制备式（IIIA）化合物或其盐的过程。
• MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：Ancliff Rachael Anne

  公开号：US20090163495A1

  公开（公告）日：2009-06-25

  There are provided according to the invention, novel compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

  根据本发明提供了新的化合物，化学式为（I），其中R1、R2、R3、R4、R5、X、a、b和Z的定义如规范中所述，制备它们的方法，包含它们的配方以及它们在治疗炎症性疾病中的应用。
• US7101882B2
  申请人：——

  公开号：US7101882B2

  公开（公告）日：2006-09-05
• US7560548B2
  申请人：——

  公开号：US7560548B2

  公开（公告）日：2009-07-14
• [EN] MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] DERIVES DE MORPHOLINE-ACETAMIDE PERMETTANT DE TRAITER LES MALADIES INFLAMMATOIRES
  申请人：GLAXO GROUP LTD

  公开号：WO2002026722A1

  公开（公告）日：2002-04-04

  Compounds of formula (I) wherein: R1 represents C¿1-16? alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y?1¿-, aryl-Y1-, heteroaryl-Y1-, aryl-(O)¿t?-aryl-Y?1¿-, aryl-(O)¿t?-heteroaryl-Y?1¿-, heteroaryl-(O)¿t?-aryl-Y?1¿-, heteroaryl-(O)¿t?-heteroaryl-Y?1¿-, C¿2-6? alkenyl-Y?1¿-, aryl-O-Y1-, heteroaryl-O-Y1-, C¿1-16? alkyl-SO2-Y?1-,M-Y1-,J2-Y1¿-, -CN or C¿3-8? cycloalkyl-Y?1¿-or C¿3-8? cycloalkenyl-Y?1¿-, which cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C¿1-16? Alkyl groups; R?2¿ represents hydrogen or C¿1-16? alkyl; X represents ethylene or a group of formula CR?eRf¿ wherein R?e and Rf¿ independently represent hydrogen or C1-14 alkyl or R?e and Rf¿ may together with the carbon atom to which they are attached form a C¿3-8? cycloalkyl group; R?3 and R4¿ independently represent hydrogen or C¿1-14? alkyl; Z represents a bond, CO, SO2, CR?9R6(CH¿2)n, (CH2)nCR?9R6, CHR6(CH¿2)nO, CHR6(CH2)nS, CHR6(CH2)nOCO, CHR6(CH2)nCO, COCHR6(CH2)n or SO2CHR6(CH2)n; n represents an integer from 0 to 4; processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.