(Z)-3,3-dimethyl-1-(vinyloxy)triaz-1-ene 2-oxide | 1152315-86-0

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 炔丙基型1，3-偶极有机化合物
• 英文名称: (Z)-3,3-dimethyl-1-(vinyloxy)triaz-1-ene 2-oxide
• CAS: 1152315-86-0
• 化学式: C₄H₉N₃O₂
• 分子量: 131.134
• InChiKey: RJDJLZZGJICIGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.9
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  (Z)-1-(2-bromoethoxy)-3,3-dimethyltriaz-1-ene 2-oxide 、 2,8,9-三甲基-2,5,8,9-四氮杂-1-磷双环(3,3,3)十一烷 以 乙腈 为溶剂， 以64%的产率得到(Z)-3,3-dimethyl-1-(vinyloxy)triaz-1-ene 2-oxide
  参考文献：
  名称：

  Improved synthesis of V-PYRRO/NO, a liver-selective nitric oxide prodrug, and analogues

  摘要：

  The reported synthesis of O-2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate(V-PYRRO/NO), a hepatoprotective agent, was cumbersome and limited by a poor overall yield of 4% from sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (PYRRO/No). We report an improved synthesis of V-PYRRO/NO in two steps with a significantly higher overall yield of 40% from PYRRO/NO. Using this protocol, a number of structural analogues of V-PYRRO/NO were prepared in good yields. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.02.103