pyridinium hydrogenmaleate | 756493-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: pyridinium hydrogenmaleate
• 英文别名: pyridine; salt of/the/ maleic acid；Pyridin; Salz der Maleinsaeure；(Z)-but-2-enedioic acid;pyridine
• CAS: 756493-25-1
• 化学式: C₄H₃O₄*C₅H₆N
• 分子量: 195.175
• InChiKey: QLSJOGIENLKPTF-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  pyridinium hydrogenmaleate 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Lutz, Chemische Berichte, 1910, vol. 43, p. 2637

  摘要：

  DOI：
• 作为产物：
  描述：

  吡啶 、 顺丁烯二酸 生成 pyridinium hydrogenmaleate 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Pfeiffer, Chemische Berichte, 1914, vol. 47, p. 1591

  摘要：

  DOI：

文献信息

• Substituted pyrazolo[1,5-a]pyridines, their preparation and use as medicaments
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2631236A1

  公开（公告）日：2013-08-28

  The present invention relates to new substituted pyrazolo[1,5-a]pyridine having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

  本发明涉及具有对西格玛受体，特别是西格玛-1受体具有很高亲和力的新取代吡唑并[1,5-a]吡啶，以及其制备方法，包含它们的组合物，以及它们作为药物的用途。
• [EN] SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINES, THEIR PREPARATION AND USE AS MEDICAMENTS<br/>[FR] PYRAZOLO[1,5-A]PYRIDINES SUBSTITUÉES, LEUR PRÉPARATION ET LEUR UTILISATION COMME MÉDICAMENTS
  申请人：ESTEVE LABOR DR

  公开号：WO2013124341A1

  公开（公告）日：2013-08-29

  The present invention relates to new substituted pyrazolo[1,5-a]pyridine having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

  本发明涉及具有对σ受体，特别是σ-1受体具有很高亲和力的新取代吡唑并[1,5-a]吡啶，以及其制备方法，包括它们的组合物，以及它们作为药物的用途。
• Assessment of Co-sublimation for the Formation of Multicomponent Crystals
  作者：Jean Lombard、Delia A. Haynes、Tanya le Roex

  DOI：10.1021/acs.cgd.0c01148

  日期：2020.12.2

  The merits of co-sublimation and mechanochemistry as screening techniques for multicomponent crystal formation are compared. Several multicomponent crystals that can be formed both mechanochemically and by sublimation are investigated, allowing for a comparison between the relatively unknown technique of co-sublimation and a well-known, robust solid-state screening methodology. This work aims to determine the general utility and versatility of co-sublimation in the preparation of multicomponent crystals. Co-crystals and salts, as well as their polymorphs, have been investigated, and problems that can arise due to sublimation temperature differences, isomerization, and degradation are discussed. Co-sublimation is shown to be a valuable co-crystallization technique for the discovery and identification of new multicomponent materials.

  比较了共升华和机械化学作为多组分晶体形成筛选技术的优点。研究了几种既能通过机械化学又能通过升华形成的多组分晶体，从而对相对未知的共升华技术和众所周知的稳健固态筛选方法进行了比较。这项工作旨在确定共升华法在制备多组分晶体方面的一般实用性和多功能性。研究了共晶体、盐及其多晶体，并讨论了由于升华温度差异、异构化和降解可能产生的问题。研究表明，共升华是发现和鉴定新型多组分材料的一种重要共结晶技术。
• METHOD FOR PRODUCING ADHESIVE PATCH, AND ADHESIVE PATCH
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：EP2700401A1

  公开（公告）日：2014-02-26

  A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug : the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.

  一种生产包括支撑层和粘合剂层的贴片的方法，包括以下步骤：使用通过混合碱金属二乙酸酯、药物和非水粘合剂基质得到的粘合剂层组合物形成粘合剂层，使药物和碱金属二乙酸酯之间的摩尔比（药物的摩尔数：碱金属二乙酸酯的摩尔数）为 1:0.5 至 1:15。
• Ogata; Tsunemitsu; Oda, 1944, vol. 23, p. 281
  作者：Ogata、Tsunemitsu、Oda

  DOI：——

  日期：——