6-chloro-1-(indol-3-yl)-1,2,3,4-tetrahydro-β-carboline | 1236398-46-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 6-chloro-1-(indol-3-yl)-1,2,3,4-tetrahydro-β-carboline
• CAS: 1236398-46-1
• 化学式: C₁₉H₁₆ClN₃
• 分子量: 321.809
• InChiKey: NQIZSICNGOCBGS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  6-chloro-1-(indol-3-yl)-1,2,3,4-tetrahydro-β-carboline 、 丁酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以67%的产率得到6-chloro-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-β-carboline
  参考文献：
  名称：

  Discovery of tetrahydro-β-carbolines as inhibitors of the mitotic kinesin KSP

  摘要：

  Inhibitors of kinesin spindle protein (KSP) are a promising class of anticancer agents that cause mitotic arrest in cells from a failure to form functional bipolar mitotic spindles. Here, we report the synthesis and biological evaluation of a novel series of tetrahydro-beta-carboline analogs based on the structure of the known KSP inhibitor HR22C16. Preferred compounds 11b, 12a and 19b were identified as potent inhibitors in a KSP ATPase assay with good anti-proliferative activity in A549 cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.024
• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以1.35 g的产率得到6-chloro-1-(indol-3-yl)-1,2,3,4-tetrahydro-β-carboline
  参考文献：
  名称：

  Discovery of tetrahydro-β-carbolines as inhibitors of the mitotic kinesin KSP

  摘要：

  Inhibitors of kinesin spindle protein (KSP) are a promising class of anticancer agents that cause mitotic arrest in cells from a failure to form functional bipolar mitotic spindles. Here, we report the synthesis and biological evaluation of a novel series of tetrahydro-beta-carboline analogs based on the structure of the known KSP inhibitor HR22C16. Preferred compounds 11b, 12a and 19b were identified as potent inhibitors in a KSP ATPase assay with good anti-proliferative activity in A549 cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.024